Association of mPRα expression with various clinicopathological characteristics and pathway biomarkers.

<p><i>Kruskal-Wallis</i> test, Chi-square test were used;</p>a<p><i>P</i> values calculated using Fisher’s exact test;</p>b<p>Additional adjusting for age, TNM stage;</p>c<p>TNM stage 0–3 vs. TNM stage 4;</p>d<p>TNM stage 0–2 vs. TNM stage 4;</p>e<p>There were two cases without grade information provided; <i>f</i> There were thirty five cases without the related information provided;</p

Correlation between mPRα expression and molecular subtypes of breast cancer.

a<p>p-value from Chi-square test for ER+ vs. HER2+ER–PR–.</p>b<p>p-value from <i>Kruskal-Wallis</i> test for ER+ vs. HER2+ER–PR–.</p

Clinicopathologic characteristics and immunohistochemical features of breast cancer patients.

<p>Clinicopathologic characteristics and immunohistochemical features of breast cancer patients.</p

Immunohistochemical stain intensities of mPRα and controls.

<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035198#pone-0035198-g001" target="_blank">Figure 1A</a> shows the western blot assay of cellular proteins (duplicates) isolated from MB231 and MB231-mPR (mPRα cDNA stably transfected MB231 cells). <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035198#pone-0035198-g001" target="_blank">Figure 1B – 1E</a> show the tissue microarray cores that are negative (1B), weak (1C), moderate (1D), and strong positive (1E). The positive stain signals are indicated as black arrows. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035198#pone-0035198-g001" target="_blank">Figure 1F</a> shows a benign breast disease core with weak mPR positive stain in epithelium (black arrow) and strong positive stain in myoepithelium (brown arrow). Image was taken a 20× lens.</p

Regional plots of breast cancer association in 1p12-11.2.

<p>Regional plot of association result, recombination hotspots and linkage disequilibrium for the 1p12-11.2:120,505,799–121,481,132 breast cancer susceptibility loci. Association result from a trend test in—log10<i>P</i>values (y axis, left; red diamond, the top ranked breast cancer associated locus in the region; blue diamond, best conditioned analysis results conditioned on rs11249433; black diamonds, genotyped SNPs; gray diamonds, imputed SNPs) of the SNPs are shown according to their chromosomal positions (x axis). Linkage disequilibrium structure based on the 1000 Genomes CEU data (n = 85) was visualized by snp.plotter software. The line graph shows likelihood ratio statistics (y axis, right) for recombination hotspot by SequenceLDhot software based on the background recombination rates inferred by PHASE v2.1. Physical locations are based on hg19. Gene annotation was based on the NCBI RefSeq genes from the UCSC Genome Browser.</p

Two independent association signals at the 1p11.2 locus: Association results for breast cancer risk among European women in BCAC, by tumor characteristic.

<p>Two independent association signals at the 1p11.2 locus: Association results for breast cancer risk among European women in BCAC, by tumor characteristic.</p

Two independent association signals at the 1p11.2 locus: Association results for breast cancer risk among women in BCAC, by ancestry.

<p>Two independent association signals at the 1p11.2 locus: Association results for breast cancer risk among women in BCAC, by ancestry.</p

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原著和名: [記載なし]科名: = unknown採集地: タイ カオヤイ国立公園 (タイ国 カオヤイ国立公園)採集日: 1984/10/13採集者: 萩庭丈壽整理番号: JH051286国立科学博物館整理番号: TNS-VS-94871