8,039 research outputs found

    EEOC v. Cracker Barrel Old Country Store, Incorporated

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    Celebrating the 125th Anniversary of the Notre Dame Law School

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    This year marks the Notre Dame Law School\u27s 125th year of continuous operation. This issue of the Notre Dame Law Review is our contribution to the anniversary celebration. We asked a few of the Law School\u27s many distinguished graduates to contribute their reflections on legal education at Notre Dame. They are Robert Michael Greene, Class of 1969; Peter T. King, Class of 1968; Patrick McCartan, Class of 1959; and Hon. Martha Vazquez, Class of 1978. We are grateful as well to Hon. Paul V. Niemeyer, Class of 1966, who prepared an essay for the issue

    Design, synthesis, and applications of bio-derived crosslinking monomers for molecular imprinting

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    Most of the research in the field of molecular imprinting has been focused on the development of new functional monomers, in order to improve the molecular recognition properties afforded by these materials. The role of the crosslinking monomer has often been overlooked, since it is considered an inert component that only provides a scaffold to support the binding sites. However, the crosslinking monomer represents a high percent (80-90%) of the composition of molecularly imprinted polymers (MIPs), which can have a large influence on the MIPs properties. This research addresses the design, synthesis, and applications of new crosslinking monomers for molecular imprinting. Crosslinking monomers containing different polymerizable groups (methacrylate/methacrylamide, methacrylamide/vinylketone, and methacrylate/vinyl ketone) were synthesized and used to prepare MIPs. Key steps in the synthesis of these monomers involved the use enzymatic methodologies to selectively deprotect methyl esters. To avoid an undesirable intramolecular Michael addition, N-methyl-N-methoxy amides derivatives were used as electrophiles to introduce the vinylketone functionality via nucleophilic addition of a Grignard reagent. Enhancement in molecular recognition properties exhibited by MIPs prepared with crosslinking monomers incorporating the amide functionality was attributed to cooperative interactions within the crosslinking with the template molecule, as well as an improved morphology that arises from the reactivity differential of the polymerizable groups. Incorporation of the binding functionality in a crosslinking format allowed to maximize the degree of crosslinking without imposing restrictions on functional group concentrations. An important breakthrough for the simplification of the molecular imprinting process was achieved by the use of a one single monomer, which incorporates an amide functionality for binding the template molecule and the polymerizable groups to form the polymeric network. The advantage of using this single monomer is that there is not need to optimize the functional/crosslinking monomer ratio. The strategy of using functionalized crosslinking monomers derived from natural amino acids, to provide the functional groups for catalytic activity was investigated using a combinatorial approach for fast screening. Finally, modification of biological matrices using bioimprinting methodologies was explored by imprinting a Class I aldolase antibody with an aldol reaction product in order to improve its catalytic activity in organic solvents

    A Business Entity By Any Other Name: Corporation, Community and Kinship

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    Forty-five years ago, the Alaska Native Claims Settlement Act resolved outstanding land claims between the federal and state government and Alaska Natives. The fund created by the settlement was used as seed money to establish the Alaska Native Corporations. The Native corporations have particular features which make them distinct from other business entities, these differences have been lauded by some shareholders but have simultaneously drawn ire from others. In 2015 the Alaska legislature introduced H.B. 49, a benefit corporation bill that would allow entrepreneurs to pursue both profits and social ends. This note traces the rise of the modern Alaska Native Corporation. It then weighs the merits of each business entity and assesses which is best aligned to improve the lives of Alaska Natives

    NACCS 37th Annual Conference

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    Chicana/o Environmental Justics Struggles for a Post-Neoliberal AgeApril 7-10, 2010Grand Hyatthttps://scholarworks.sjsu.edu/naccs_programs/1027/thumbnail.jp

    EEOC v. RJB Properties, INC. and Blackstone Consulting, INC.,

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