Transcultural adaptation and validation of the "Adult Eosinophilic Esophagitis Quality of Life Questionnaire" into Spanish

Background: The "Adult Eosinophilic Esophagitis Quality of Life (EoE-QoL-A) Questionnaire" was developed in English as a valid, reliable, and disease-specific health-related QoL measure. This research aims to adapt and validate this questionnaire for Spanish-speaking patients. Patients and methods: A multicenter, observational, prospective study was conducted at 8 Spanish hospitals. The cultural adaptation of the original EoE-QoL-A questionnaire was undertaken through a standardized 3-phase procedure: 1. Translation; 2. Retrotranslation; and 3. Pilot study. Patients completed the Hospital Anxiety and Depression Scale (HADS), the Short Form (SF)-12, the Brief Illness Perception Questionnaire (BIPQ), and the adapted EoE-QoL-A, with a retest 3 months later. Statistical analysis included construct validity, internal consistency, criterion validity, and reproducibility. Results: One hundred and seventy adult EoE patients (73.5 % male; aged 33.5 ± 11.4-y) were included in the study. With regard to internal validity, all Cronbach alpha values were > 0.75. A significant correlation between items assessed in the SF-12, BIPQ and EoE-QoL-A questionnaires (p < 0.001) was observed. Correlations with the HADS were stronger for anxiety than for depression levels. Anxiety related to disease diagnosis and choking were the most affected dimensions; less affected were the dimensions related to eating, social, and emotional development. Intraclass correlation coefficients between the test and retest assessments were acceptable for all questionnaires, with the highest values (0.73-0.84) calculated for the EoE-QoL-A Spanish version. Conclusion: The Spanish version of the EoE-QoL-A is a reliable, valid, and responsive questionnaire. Diagnosis and choking anxiety were the most affected dimensions in the health-related QoL in adult EoE patients

Patients non linked to their referents during the pandemic

Abstract The pandemic has gotten a high impact in mental health including general population and patients with mental illness before the pandemic, who has seen increase their symptoms and/or their treatment interrupted. This letter aims to describe the sociodemographic and clinical variables that converge in patients who come to the psychiatry emergency department during the pandemic without being under prior follow-up at least the previous six months. The database was obtained through a retrospective review of digital medical record, which registers sociodemographic, diagnosis, reason for consultation and hospital admissions. The observatory periods were: 1) Before the lockdown, from 13th of January, 2020 to 14th of March, 2020; 2) During the lockdown by the first alarm state, from the beginning of the alarm state in Spain (15th of March, 2020) until its end (20th of June, 2020) and 3) while the second state of alarm in Spain (from the 25th of October, 2020 to 9th of May, 2021). In the first state of alarm the psychotic decompensations increased from 5.1% before the pandemic to 12.5% (p=0.015), and the unipolar depression decreased from 15.3% to 9.3% (p=0.026). About the therapeutic decision, stands out that in the first alarm state the hospitalizations increased to 30.6% while before the lockdown the income was 21% (p=0.039). During the second state of alarm the number of pacients without previous follow-up increased from 22.4% to 29.4% (p<0.001). They were also younger with an average age of 38.8 years (p=0.006) and only the 29.5% had couple (p=0.004). In conclusion, this study suggests that in the first state of alarm the epidemiological situation limited face-to-face health care, which is why the hospital admission was preferred specially in psychotic decompensations. While in the second alarm state more users attended without previous follow-up, without couple and younger