3 research outputs found
Influenece of novel 1,4-dihydropyridine derivatives on rats memories procesies
MÅ«sdienu intensÄ«vais dzÄ«ves ritms un ikdienas stress nelabvÄlÄ«gi ietekmÄ organismu. CilvÄki piekopj neveselÄ«gu dzÄ«vesveidu. Arvien jaunÄkiem cilvÄkiem konstatÄ hroniskas saslimÅ”anas, kuru ÄrstÄÅ”anÄ ilgstoÅ”i ir jÄlieto zÄles. ZÄļu lietoÅ”ana un stress bojÄ atmiÅu. BojÄta atmiÅa traucÄ cilvÄkam pilnvÄrtÄ«gi pildÄ«t savas funkcijas. TÄpÄc tiek meklÄti jauni lÄ«dzekļi kognitÄ«vo funkciju uzlaboÅ”anai, kas bÅ«tu vÄl efektÄ«vÄki, ar mazÄku toksiskumu un blaknÄm.
IepriekÅ”Äjos pÄtÄ«jumos 1,4-dihidropiridÄ«ni (DHP) ir uzrÄdÄ«juÅ”i neiroprotektÄ«vas Ä«paŔības. Å ajÄ darbÄ pÄtÄ«jÄm jaunus Latvijas OrganiskÄs sintÄzes institÅ«tÄ sintezÄtus 1,4-dihidropiridÄ«nu savienojumus, kas satur N-propargilgrupu (D3-69, D3-72, D3-72-2) vai adamantilgrupu (AV-6-93). Bez tam D3-72-2 satur arÄ« dodecilpiridÄ«nija grupu. KÄ atsauces vielas izmantojÄm amantadÄ«nu, rasagilÄ«nu (propargilgrupu saturoÅ”u antidepresantu),kontrolei fizioloÄ£isko Ŕķīdumu.FarmakoloÄ£iskos testos noskaidrojÄm to ietekmi uz atmiÅu procesu veidoÅ”anos žurkÄm.Nowadays intense rhythm of life and eveyday stress affects the organism. People are pursuing an unhealthy lifestyle. More young people have got chronic diseases and had to take medicine for long term. Medicines and stress damage memory. Damaged memory interferes with a person to perform his or her functions perfectly. Therefore new resources to improve cognitive function are being searched for years. They should be more effective, with less toxicity and side effects. Previous studies of 1,4-dihydropyridine (DHP) derivatives have shown their neuroprotective properties. The present study was devoted to the pharmacological investigation of novel DPH coumpounds containing N-propargylgroup (D3-69, D3-72, D3-72-2) and adamantylgroup (AV-6-93) synthesised at Latvian Institute of Organic Synthesis. D3-72-2 also contains the dodecylpyridiniumgroup. Compounds were administered intraperitoneally to rats for 7, 14 days. Control groups received saline and/or reference drugs amantadine, rasagiline