Inferior Olive HCN1 Channels Coordinate Synaptic Integration and Complex Spike Timing

Acknowledgments This work was supported by the Medical Research Council (G0501216), the Wellcome Trust (093295/Z/10/Z and 086602/Z/08/Z), and the BBSRC (Bb/H020284/1). We thank Paolo Puggioni for help with motion analysis and the IMPACT facility at the University of Edinburgh for imaging resources.Peer reviewe

Extraction of synaptic input properties in vivo

Knowledge of synaptic input is crucial for understanding synaptic integration and ultimately neural function. However, in vivo, the rates at which synaptic inputs arrive are high, so that it is typically impossible to detect single events. We show here that it is nevertheless possible to extract the properties of the events and, in particular, to extract the event rate, the synaptic time constants, and the properties of the event size distribution from in vivo voltage-clamp recordings. Applied to cerebellar interneurons, our method reveals that the synaptic input rate increases from 600 Hz during rest to 1000 Hz during locomotion, while the amplitude and shape of the synaptic events are unaffected by this state change. This method thus complements existing methods to measure neural function in vivo

Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus (dataset 4)

Multichannel electrophysiology data for the manuscript with the same title

Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus (dataset 5)

Multichannel electrophysiology data for the manuscript with the same title

Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus (dataset 9)

Multichannel electrophysiology data for the manuscript with the same title. (2305_20

Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus (dataset 3)

Multichannel electrophysiology data for the manuscript with the same title

Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus (dataset 8)

Multichannel electrophysiology data for the manuscript with the same title. (2306_24

Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus (dataset 6)

Multichannel electrophysiology data for the manuscript with the same title