Pyrethroids and Breast Cancer Risk Bibliography

Bibliography on the breast cancer risk of pyrethroid insecticidesBibliography on the breast cancer risk of pyrethroid insecticides. Includes review articles, references on cancer risk, genotoxicity, immunotoxicity, endocrine disruption, and exposure from food residues, occupational exposure, household exposure, and environmental fate.New York State Department of Health and Department of Environmental Conservatio

Luminous Satellites II: Spatial Distribution, Luminosity Function and Cosmic Evolution

We infer the normalization and the radial and angular distributions of the number density of satellites of massive galaxies ($\log_{10}[M_{h}^*/M\odot]>10.5$) between redshifts 0.1 and 0.8 as a function of host stellar mass, redshift, morphology and satellite luminosity. Exploiting the depth and resolution of the COSMOS HST images, we detect satellites up to eight magnitudes fainter than the host galaxies and as close as 0.3 (1.4) arcseconds (kpc). Describing the number density profile of satellite galaxies to be a projected power law such that P(R)\propto R^{\rpower}, we find \rpower=-1.1\pm 0.3. We find no dependency of \rpower on host stellar mass, redshift, morphology or satellite luminosity. Satellites of early-type hosts have angular distributions that are more flattened than the host light profile and are aligned with its major axis. No significant average alignment is detected for satellites of late-type hosts. The number of satellites within a fixed magnitude contrast from a host galaxy is dependent on its stellar mass, with more massive galaxies hosting significantly more satellites. Furthermore, high-mass late-type hosts have significantly fewer satellites than early-type galaxies of the same stellar mass, likely a result of environmental differences. No significant evolution in the number of satellites per host is detected. The cumulative luminosity function of satellites is qualitatively in good agreement with that predicted using subhalo abundance matching techniques. However, there are significant residual discrepancies in the absolute normalization, suggesting that properties other than the host galaxy luminosity or stellar mass determine the number of satellites.Comment: 23 pages, 12 figures, Accepted for publication in the Astrophysical Journa

Moving the Needle: A Reflection on Five Years of Investment in Oregons Affordable Housing Landscape

What did five years and $16 million in investment in affordable housing mean for Meyer Memorial Trust and its partners active in affordable housing efforts across Oregon?In our report, Moving the Needle: A Reflection on Five Years of Investment in Oregon's Affordable Housing Landscape, Meyer staff reflects back on the challenges, setbacks, clear "wins" and lessons learned from designing and implementing a strategic philanthropic initiative.  In addition to robust and lively discussions among the team about what we take forward from this work, we reached out to dozens of key partners in nonprofits, other funders and government to get more perspective on how the Affordable Housing Initiative was received.

Point-by-point inscription of apodized fiber Bragg gratings

We demonstrate apodized fiber Bragg gratings inscribed with a point-by-point technique. We tailor the grating phase and coupling amplitude through precise control over the longitudinal and transverse position of each laser-inscribed modification. This method of apodization is facilitated by the highly-localized, high-contrast modifications generated by focussed IR femtosecond laser inscription. Our technique provides a simple method for the design and implementation of point-by-point fiber Bragg gratings with complex apodization profiles.Comment: 6 pages, 4 figures, article in revie

Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment.

Predictive biomarkers have the potential to facilitate cancer precision medicine by guiding the optimal choice of therapies for patients. However, clinicians are faced with an enormous volume of often-contradictory evidence regarding the therapeutic context of chemopredictive biomarkers.We extensively surveyed public literature to systematically review the predictive effect of 7 biomarkers claimed to predict response to various chemotherapy drugs: ERCC1-platinums, RRM1-gemcitabine, TYMS-5-fluorouracil/Capecitabine, TUBB3-taxanes, MGMT-temozolomide, TOP1-irinotecan/topotecan, and TOP2A-anthracyclines. We focused on studies that investigated changes in gene or protein expression as predictors of drug sensitivity or resistance. We considered an evidence framework that ranked studies from high level I evidence for randomized controlled trials to low level IV evidence for pre-clinical studies and patient case studies.We found that further in-depth analysis will be required to explore methodological issues, inconsistencies between studies, and tumor specific effects present even within high evidence level studies. Some of these nuances will lend themselves to automation, others will require manual curation. However, the comprehensive cataloging and analysis of dispersed public data utilizing an evidence framework provides a high level perspective on clinical actionability of these protein biomarkers. This framework and perspective will ultimately facilitate clinical trial design as well as therapeutic decision-making for individual patients