Charge, geometry, and effective mass in the Kerr-Newman solution to the Einstein field equations

It has been shown that for the Reissner-Nordstrom solution to the vacuum Einstein field equations charge, like mass, has a unique space-time signature [Found. Phys. 38, 293-300 (2008)]. The presence of charge results in a negative curvature. This work, which includes a discussion of effective mass, is extended here to the Kerr-Newman solution.Comment: To appear in Foundations of Physics. Misprints have been corrected. 14 pages, 4 figure

The Emission of Electromagnetic Radiation from Charges Accelerated by Gravitational Waves and its Astrophysical Implications

We provide calculations and theoretical arguments supporting the emission of electromagnetic radiation from charged particles accelerated by gravitational waves (GWs). These waves have significant indirect evidence to support their existence, yet they interact weakly with ordinary matter. We show that the induced oscillations of charged particles interacting with a GW, which lead to the emission of electromagnetic radiation, will also result in wave attenuation. These ideas are supported by a small body of literature, as well as additional arguments for particle acceleration based on GW memory effects. We derive order of magnitude power calculations for various initial charge distributions accelerated by GWs. The resulting power emission is extremely small for all but very strong GWs interacting with large quantities of charge. If the results here are confirmed and supplemented, significant consequences such as attenuation of early universe GWs could result. Additionally, this effect could extend GW detection techniques into the electromagnetic regime. These explorations are worthy of study to determine the presence of such radiation, as it is extremely important to refine our theoretical framework in an era of active GW astrophysics.Comment: Appears in Gravitational Wave Astrophysics, Editor C.F. Sopuerta, Astrophysics and Space Science Proceedings, Volume 40. ISBN 978-3-319-10487-4. Springer International Publishing Switzerland, 2015, p. 30

Status of the Resource Room Model in Local Education Agencies: A Descriptive Study

Although resource room programs are widely used, only limited information is available on implementation of this model. The purpose of the present investigation was to survey a nationwide sample of local education agencies (LEAs) to determine the status of this model at the local level and to identify the characteristics of resource programs as they are currently implemented. A questionnaire was sent to a 5% stratified random sample of LEAs with a 53.4% response rate. Results indicated that most local education agencies use resource room programs, and have done so for at least three years. Most programs are multicategorical. The majority of respondents indicated that they believed the programs were effective, and that they would continue to be used. A major conclusion from this study relates to the need for descriptions of model resource room programs and practices.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

IgG 3 + B cells are associated with the development of multiple sclerosis

Objectives Disease‐modifying therapies (DMTs) targeting B cells are amongst the most effective for preventing multiple sclerosis (MS) progression. IgG3 antibodies and their uncharacterised B‐cell clones are predicted to play a pathogenic role in MS. Identifying subsets of IgG3+ B cells involved in MS progression could improve diagnosis, could inform timely disease intervention and may lead to new DMTs that target B cells more specifically. Methods We designed a 31‐parameter B‐cell‐focused mass cytometry panel to interrogate the role of peripheral blood IgG3+ B cells in MS progression of two different patient cohorts: one to investigate the B‐cell subsets involved in conversion from clinically isolated syndrome (CIS) to MS; and another to compare MS patients with inactive or active stages of disease. Each independent cohort included a group of non‐MS controls. Results Nine distinct CD20+IgD−IgG3+ B‐cell subsets were identified. Significant changes in the proportion of CD21+CD24+CD27−CD38− and CD27+CD38hiCD71hi memory B‐cell subsets correlated with changes in serum IgG3 levels and time to conversion from CIS to MS. The same CD38− double‐negative B‐cell subset was significantly elevated in MS patients with active forms of the disease. A third CD21+CD24+CD27+CD38− subset was elevated in patients with active MS, whilst narrowband UVB significantly reduced the proportion of this switched‐memory B‐cell subset. Conclusion We have identified previously uncharacterised subsets of IgG3+ B cells and shown them to correlate with autoimmune attacks on the central nervous system (CNS). These results highlight the potential for therapies that specifically target IgG3+ B cells to impact MS progression

IDPpi:Protein-protein interaction analyses of human intrinsically disordered proteins

Intrinsically disordered proteins (IDPs) are characterized by the lack of a fixed tertiary structure and are involved in the regulation of key biological processes via binding to multiple protein partners. IDPs are malleable, adapting to structurally different partners, and this flexibility stems from features encoded in the primary structure. The assumption that universal sequence information will facilitate coverage of the sparse zones of the human interactome motivated us to explore the possibility of predicting protein-protein interactions (PPIs) that involve IDPs based on sequence characteristics. We developed a method that relies on features of the interacting and non-interacting protein pairs and utilizes machine learning to classify and predict IDP PPIs. Consideration of both sequence determinants specific for conformational organizations and the multiplicity of IDP interactions in the training phase ensured a reliable approach that is superior to current state-of-the-art methods. By applying a strict evaluation procedure, we confirm that our method predicts interactions of the IDP of interest even on the proteome-scale. This service is provided as a web tool to expedite the discovery of new interactions and IDP functions with enhanced efficiency. © 2018 The Author(s)