Combined flow and pressure measurements in coronary artery disease

Westerhof, N. [Promotor]Visser, F.C. [Promotor

Implantable Sensor System for Remote Detection of a Restenosis Condition

Part 7: Perceptional SystemsInternational audienceThe increase of life expectancy in the European Union, and the high risk of cardiovascular diseases associated with age, are some of the main factors to contribute to the rise of healthcare costs. An intelligent stent (e-stent), capable of obtaining and transmitting real-time measurements of physiological parameters for its clinical consultation, can be a useful tool for long-term monitoring, diagnostic, and early warning system for arterial blockage without patient hospitalization. In this paper, a behavioural model of capacitive Micro-Electro-Mechanical (MEMS) pressure sensor is proposed and simulated under several restenosis conditions. Special attention has been given to the need of an accurate fault model, obtained from realistic finite-element simulations,to ensure long-term reliability; particularly for those faults whose behavior cannot be easily described by an analytical model

The diastolic flow velocity-pressure gradient relation and dpv50 to assess the hemodynamic significance of coronary stenoses

To evaluate the hemodynamic impact of coronary stenoses, the fractional (FFR) or coronary flow velocity reserve (CFVR) usually is measured. The combined measurement of instantaneous flow velocity and pressure gradient (v-dp relation) is rarely used in humans. We derived from the v-dp relation a new index, d