44 research outputs found
Open and hidden strangeness with kaons and -mesons in Bjorken energy density approach for central A+A collisions from SPS to LHC
We use the available data on for the identified
hadrons including , , ,
and -mesons, registered at midrapidity ( in central 0-5% Au-Au, Pb-Pb and Xe+Xe collisions in a broad range of
energies in order to compare the relative contributions to the Bjorken energy
density. Particles, like strangeness-neutral -meson (a system of
quarks) and K-meson (containing single s-quark), are of
specific interest because they might have different production mechanisms and
differ in sensitivity to the properties of the QGP-medium formed in
relativistic heavy-ion collisions.Comment: 9 pages, 2 figures, XXV Baldin ISHEP
Antimutagenic properties of several kinds of rice as tested upon yeast strain Saccharomyces cerevisiae D7
The aim of this work was to study antimutagenic and antioxidant properties of water extracts of various types of rice. Antioxidant activity, total phenolic andflavonoid contents were measured spectrophotometrically. Individual phenolics β catechins, catechin gallates, ferulic acid β were analysed by HPLC/PDA. Antimutagenic activity of rice extracts was tested using unicellular eukaryotic yeast strain Saccharomyces cerevisiae D7 the first time.Non-processed rice types contained substantially higher amount of soluble total and individual phenolics and had higher antioxidant activity than peeled rice. Parboiled rice, in which technological processing helps to maintain active substances inside the grains, exhibited also relatively high phenolic levels. The highest antimutagenic effect was proved in Indian Rice, Arborio, Jasmine Rice and Three Colours Rice independently of rice extract concentration. Because of relatively high values of phenolics and high antioxidant activity, the antimutagenic activity of these samples could be attributed to biologically active phenolics present mainly in the bran layer of whole rice grain
Comparative Analysis of Clinical, Hormonal and Morphological Studies in Patients with Neuroendocrine ACTH-Producing Tumours
This paper highlights the problem of neuroendocrine tumours (NETs) with clinical symptoms of hypercorticism caused by hypersecretion of adrenocorticotropic hormone (ACTH) by tumour cells. In most cases (85%), the tumours were localized in the pituitary gland (Cushing's disease); 15% of the patients had an extrapituitary tumour that manifest as an ectopic ACTH secretion (EAS).
Comparative analysis of clinical, hormonal, histological, and immunohistochemical characteristics of pituitary and extrapituitary ACTH-secreting NET was performed. It included 46 patients with CD and 38 ones exhibiting ectopic ACTH secretion (EAS). Results of the study suggest differences between CD and EAS in terms of the severity of clinical manifestations and duration of the disease. Hormonal studies showed that EAS unlike CD was associated with high plasma ACTH and cortisol levels, late-evening salivary cortisol and daily urinary free cortisol, the absence of a 60% or greater reduction of cortisol in the HDDST test, and the presence of a low (less than 2) ACTH gradient in response to desmopressin administration with catheterization of cavernous sinuses. The study of morphofunctional characteristics of the removed NET demonstrated the ability of both pituitary and extrapituitary NETs to express ACTH as well as GH, PRL, LH, and FSH. The angiogenic markers (CD31 and VEGF) were detected with equal frequency regardless of the NET localization. The histological structure of all corticotropinomas suggested their benign origin, but extrapituitary NETs were represented by different morphological types with varying malignancy, invasiveness, and metastatic properties. A higher cell proliferation potential (Ki-67) was documented for NET in patients presenting with an ectopic ACTH secretion compared to those having corticotropinomas
Clinical guidelines βHyperprolactinemiaβ (draft)
Hyperprolactinemia is a persistent excess of the blood serum prolactin. The syndrome contains various symptoms, the most characteristic is a violation of the reproductive system. There are multiple endogenous and exogenous causes of hyperprolactinemia. The main treatment method is dopamine agonist therapy, in case of prolactinoma existence, surgical and radiation methods can be applied. About 15% of patients are resistant to dopamine agonist therapy, which determines creation of individual management tactics. The article presents a draft of clinical guidelines for the diagnosis and treatment of hyperprolactinemia, which provides a modern examination algorithm, discusses the basic principles of diagnostics and treatment approaches
Monitoring of growth and production characteristics of red yeasts cultivated on hydrothermally pretreated lignocellulosic pine material
The aim of this work was to compare the production of carotenes and ergosterol by red yeasts grown on pine lignocellulose substrates. The yeast strains Rhodotorula aurantiaca and Sporobolomyces shibatanus were grown on the liquid fraction of steam pretreated pine (210 Β°C, catalyst SO2). Biomass production on a pine hydrolysate was lower than on glucose. The highest content of carotenoids and ergosterol in the cells of R. aurantiaca grown on pine hydrolysate was about 1.7 mg g-1 and 0.8 mg g-1 (dwt), respectively, and in S. shibatanus about 0.9 mg g-1 and 0.1 mg g-1, respectively. Hemicellulose hydrolysates may contain many compounds that have inhibitory effects on microorganisms. In this work, the influences of some inhibitors were assessed by cultivating yeasts on media with a representative addition of the selected compounds. From these tests, furfural appears to be the most critical inhibitor, whereas acetic acid and 5-hydroxymethyl furfural (HMF) do not affect the growth so much
PROSPECTS AND PROBLEMS OF USING THE EFFECT OF SURFACE-ENHANCED RAMAN SCATTERING IN THE DIAGNOSIS OF VIRAL INFECTIONS
This review presents the latest advances in the use of surface-enhanced Raman scattering (SERS) immunoassay, which can be used to detect viral markers. As in the case of conventional immunoassays, these methods are often based on Β«sandwich-typeΒ» solid phase immunoassay. In recent years the necessary components of the immunochemical methods with SERS detection is SERS-active substrates to create a variety of approaches have been developed. Despite the difficulty of achieving high sensitivity and specificity in the analysis of clinical samples, a number of successful examples with promising results have been demonstrated
ACTH-producing neuroendocrine tumor of thymus with recurrences. Clinical case
One of the most difficult in diagnostic and treatment options for endogenous Cushing is the ectopic ACTH syndrome, which causes the development of tumors of different histogenesis localization producing adrenocorticotropic hormone (ACTH), and much less - corticotropin hormone (CRH). ACTH-secreting tumors varied in location, morphological structure and the degree of malignancy. Most of these tumors are characterized by an aggressive course with a propensity to metastasize and relapse. The article presents data of the prevalence, pathogenesis of ectopic ACTH tumors localized in the thymus, analyzis of clinical, morphological features, the methods of diagnosis and treatment. Based on the current literature, the world and our own experience on the diagnosis and treatment of patients with ectopic ACTH syndrome with localization of hormone production in the thymus, we want to highlight the current state of the problem in order to create the most efficient algorithm for diagnostic search and treatment of this difficult group of patients
Khirurgicheskoe lechenie patsientov s bolezn'yu Itsenko-Kushinga
ΠΠΎΠ»Π΅Π·Π½Ρ ΠΡΠ΅Π½ΠΊΠΎ-ΠΡΡΠΈΠ½Π³Π° ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ΅Π΄ΠΊΠΈΠΌ ΠΈ ΡΡΠΆΠ΅Π»ΡΠΌ Π½Π΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ, ΠΏΡΠΈΡΠΈΠ½ΠΎΠΉ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ, Π² Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ ΡΠ»ΡΡΠ°Π΅Π², ΡΠ²Π»ΡΠ΅ΡΡΡ Π°Π΄Π΅Π½ΠΎΠΌΠ° Π³ΠΈΠΏΠΎΡΠΈΠ·Π°, ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ°ΡΡΡ ΠΈΠ· Π°Π΄ΡΠ΅Π½ΠΎΠΊΠΎΡΡΠΈΠΊΠΎΡΡΠΎΠΏΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΡΠΎ, Π² ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ, ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΠΎΠΉ Π²ΡΡΠ°Π±ΠΎΡΠΊΠ΅ Π°Π΄ΡΠ΅Π½ΠΎΠΊΠΎΡΡΠΈΠΊΠΎΡΡΠΎΠΏΠ½ΠΎΠ³ΠΎ Π³ΠΎΡΠΌΠΎΠ½Π° (ΠΠΠ’Π), Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠ΅ΠΉ ΠΊΠΎΡΡ Π½Π°Π΄ΠΏΠΎΡΠ΅ΡΠ½ΠΈΠΊΠΎΠ² ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π³ΠΈΠΏΠ΅ΡΠΊΠΎΡΡΠΈΡΠΈΠ·ΠΌΠ° Ρ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅ΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΉ [5, 8, 11]. ΠΠΏΠ΅ΡΠ²ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ Π±ΡΠ»ΠΎ ΠΎΠΏΠΈΡΠ°Π½ΠΎ Π² 1912 Π³. Π°ΠΌΠ΅ΡΠΈΠΊΠ°Π½ΡΠΊΠΈΠΌ Π½Π΅ΠΉΡΠΎΡ
ΠΈΡΡΡΠ³ΠΎΠΌ Π. ΠΡΡΠΈΠ½Π³ΠΎΠΌ ΠΈ Π²ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΈ Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠΎ ΠΎΡ Π½Π΅Π³ΠΎ Π² 1924 Π³. ΡΡΡΡΠΊΠΈΠΌ Π½Π΅Π²ΡΠΎΠ»ΠΎΠ³ΠΎΠΌ Π.Π. ΠΡΠ΅Π½ΠΊΠΎ. Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π΄Π²Π° ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄Π° Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΠΠ: Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ (ΡΡΠ°Π½ΡΠ½Π°Π·Π°Π»ΡΠ½ΠΎΠ΅ ΠΈΠ»ΠΈ ΡΡΠ°Π½ΡΠΊΡΠ°Π½ΠΈΠ°Π»ΡΠ½ΠΎΠ΅ ΡΠ΄Π°Π»Π΅Π½ΠΈΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ) ΠΈ Π»ΡΡΠ΅Π²ΠΎΠΉ (ΠΏΡΠΎΡΠΎΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ, Β«Π³Π°ΠΌΠΌΠ°-Π½ΠΎΠΆΒ» ΠΈ Π΄Ρ.). ΠΠΎ Π΄Π°Π½Π½ΡΠΌ ΡΠ°Π·Π½ΡΡ
Π°Π²ΡΠΎΡΠΎΠ² [4, 9, 10] ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΠ° Π΄ΡΡΠ³ Ρ Π΄ΡΡΠ³ΠΎΠΌ ΠΈ Π΄ΠΎΡΡΠΈΠ³Π°Π΅Ρ ΠΏΠΎΡΡΠ΄ΠΊΠ° 80-90%. ΠΠ°ΠΆΠ΄ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΈΠΌΠ΅Π΅Ρ ΡΠ²ΠΎΠΈ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ, ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΡ ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΡ. Π’Π°ΠΊ, Π½Π°ΠΏΡΠΈΠΌΠ΅Ρ, ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ Π°Π΄Π΅Π½ΠΎΠΌΡ Π³ΠΈΠΏΠΎΡΠΈΠ·Π° ΠΎΡΠ΄Π°Π΅ΡΡΡ ΠΏΡΠ΅Π΄ΠΏΠΎΡΡΠ΅Π½ΠΈΠ΅ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΠΌΠ΅ΡΠΎΠ΄Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ, Π° ΠΏΡΠΈ Π΅Π΅ ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ Π»ΡΡΠ΅Π²ΠΎΠΌΡ [2, 3]. Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠΈΠΊΡΠΎΡ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Ρ
Π½ΠΈΠΊΠΈ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΠΈ, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ» Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΏΠΎΠ²ΡΡΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π°, ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ ΡΠ²Π΅ΡΡΠΈ ΠΊ Π½ΡΠ»Ρ ΡΠΈΡΠ»ΠΎ ΡΠ΅ΡΡΠ΅Π·Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ ΠΈ Π»Π΅ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡ
ΠΎΠ΄ΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ ΠΌΠΈΠ½ΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΡΠ°ΡΡΠΎΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ°ΠΊΠΈΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ, ΠΊΠ°ΠΊ Π½Π΅ΡΠ°Ρ
Π°ΡΠ½ΡΠΉ Π΄ΠΈΠ°Π±Π΅Ρ, ΠΏΠ°Π½Π³ΠΈΠΏΠΎΠΏΠΈΡΡΠΈΡΠ°ΡΠΈΠ·ΠΌ, Π½Π°Π·Π°Π»ΡΠ½Π°Ρ Π»ΠΈΠΊΠ²ΠΎΡΠ΅Ρ ΠΈ Π΄Ρ