Frequency of Tuberculosis Cases (defaulters) and Controls (cured) in the period of 2005 to 2010 – Amazonas State.

<p>2010* included cases that had information on treatment completion at SINAN in June 2011.</p

Registered TB patients and selection of cases and controls, Amazonas State, Brazil, 2005–2010.

<p>Registered TB patients and selection of cases and controls, Amazonas State, Brazil, 2005–2010.</p

Univariate and Multivariate logistic regression analysis of factors independently associated with treatment default for tuberculosis patients from Amazonas State, Brazil 2005–2010.

<p>Treated living area: if the treatment was provided in the area where the patient lives. Living in Manaus: if the patient was living in the capital Manaus during treatment. Living area: the type of area where the patient lives: urban, periurban (near to urban areas but developing rural and urban activities), rural. Treatment type: the type of entrance of patient, if new case, if had received previous TB treatment but default, if was a relapse case or if transferred from another health unity. Clinical form: if TB case was pulmonary, extra pulmonary or mixed (pulmonary+extrapulmonary). AFB sputum smear: results of acid fast bacilli in sputum smear. HIV: results of serology or rapid test at moment of notification or during treatment. Aids: patients presenting Aids according WHO/MoH criteria at moment of notification. Alcoholism: condition recognized and declared by the patient at moment of notification. Diabetes (Diabetes mellitus): patient under treatment at moment of diagnosis, information registered in the patient file or declared by the patient. Mental disorders: condition declared at moment of diagnosis by patient's tutor or health professional or registered in the patient file. Other comorbidities: comorbidities not included in the standard questioner but declared by patients: heart disease, liver disease, kidney disease, neurological disease, cancer, mental disorders, and chemical dependency to illicit drugs. DOT: Directly Observed Treatment. Education level: ≤basic, comprehend illiterate and education up to 8 years of study; >basic: education above 8 years of study. Race: declared by patient at moment of notification. Age: Age of the patient at moment of diagnosis.</p

Odds ratio and confidence interal of 95% for the Tuberculosis Skin Test positive results according to time of exposure (months) to index case.

<p>Odds ratio and confidence interal of 95% for the Tuberculosis Skin Test positive results according to time of exposure (months) to index case.</p

Bivariate analysis and Multivariate logistic regression for TST results and QFT results.

<p>TST: Tuberculin Skin Test, QFT: QuantiFERON-TB Gold In-Tube, MTC-score: <i>Mycobacterium tuberculosis</i> contact score, BCG: Bacillus Calmette-Guérin.</p>#<p>Categorical variables expressed as percentage (%) and quantitative variables expressed as mean and interquartile range (IQR).</p>a<p>In the 12 weeks prior to the study.</p>b<p>Linear odds ratio.</p

Multivariate logistic regression according to factors for positive QFT results stratified by TST results.

<p>TST: Tuberculin Skin Test, QFT: QuantiFERON-TB Gold In-Tube, MTC-score: <i>Mycobacterium tuberculosis</i> contact score, BCG: Bacillus Calmette-Guérin.</p>a<p>logistic regression coefficient related to quantitative variable.</p>b<p>Linear odds ratio; exponential to the regression coefficient.</p

Baseline demographic and clinical data of the study participants.

<p>TST: Tuberculin Skin Test, QFT: QuantiFERON-TB Gold In-Tube, MTC-score: <i>Mycobacterium tuberculosis</i> contact score, BCG: Bacillus Calmette-Guérin.</p>#<p>Categorical variables expressed as number of subjects (n) and percentage (%) compared to those evaluated with the characteristic studied. Quantitative variables expressed as mean and interquartile range (IQR).</p>a<p>In the 12 weeks prior to the study.</p>b<p>Risk of malnutrition was defined as a Z score for weight less than −1 SDs for age and gender; malnutrition was defined −2 SDs for age and gender.</p

Odds ratio and confidence interval of 95% for the Tuberculin Skin Test –TST− (blue) and QuantiFERON-TB Gold in-Tube –QFT− (red) positive results according to the intensity of exposure to index case by <i>Mycobacterium tuberculosis</i> contact score (MTC-score).

<p>The MTC-score is from 0 to 15 and is based on the assumption that the gradient of <i>Mtb</i> exposure is a composite function of the infectivity of the index case (0–4), the duration of exposure -hours per day- (0–4), the relationship to index case (0–4) and the type of exposure (0–3).</p

Comparison of the main variables according to TST and QFT results.

<p>IQR: interquartile range,</p><p>N₁: number of subjects, TST: Tuberculin Skin Test, QFT: QuantiFERON-TB Gold In-Tube, MTC-score: <i>Mycobacterium tuberculosis</i> contact score, n: number of subjects with intestinal helminths;</p><p>N₂: number of subjects studied for helminths.</p

Comparison of the TST and QFT results.

<p>TST: Tuberculin Skin Test, QFT: QuantiFERON-TB Gold In-Tube, n: number of subjects.</p