4 research outputs found

    Effects of Zika infection on growth

    No full text
    Objectives: To present the currently available evidence of the effects of congenital Zika virus infection on infant growth, to discuss possible intervening factors, and to describe preliminary data on this growth in a cohort of exposed children. Source of data: Non-systematic review in PubMed, BVS, CAPES, Scopus, Web of Science, Cochrane and Google Scholar databases in the last 5 years, using the terms infection/disease by Zika virus and growth/nutrition/nutritional status/infant nutrition and nutritional needs. Additionally, the anthropometric data of the first 2.5 years of a cohort of children exposed to the Zika virus during pregnancy were reviewed. Synthesis of data: Both intrauterine growth restriction and low birth weight were reported in series of cases of children with congenital Zika syndrome. The postnatal growth deficit of these children appears to be directly proportional to the degree of neurological impairment. The etiology is multifactorial, and nutritional and non-nutritional factors are probably involved. The data from the present cohort show that the head circumference evolution depends on this measurement at birth and that weight-height growth has a trend toward lower weight and length in children with congenital microcephaly and normocephalic at birth who develop some neurological abnormality. Conclusions: The few existing data suggest that, in children with congenital Zika, the greater the degree of neurological impairment, the greater the impact on growth, whether or not associated with microcephaly at birth. Resumo: Objetivos: Apresentar as evidĂȘncias atualmente disponĂ­veis das repercussĂ”es da infecção congĂȘnita pelo vĂ­rus Zika no crescimento infantil, discutir possĂ­veis fatores intervenientes e descrever dados preliminares desse crescimento em uma coorte de crianças expostas. Fonte dos dados: RevisĂŁo nĂŁo sistemĂĄtica nos portais de banco de dados PubMed, BVS, Capes, Scopus, Web of Science, Cochrane e Google Scholar nos Ășltimos cinco anos, com o uso dos termos infecção/doença pelo vĂ­rus Zika e crescimento/nutrição/status nutricional/nutrição infantil e necessidades nutricionais. AlĂ©m disso, foram revistos os dados antropomĂ©tricos dos primeiros dois anos e meio de uma coorte de crianças expostas ao vĂ­rus Zika durante a gestação. SĂ­ntese dos dados: Tanto a restrição do crescimento intrauterino como o baixo peso ao nascer tĂȘm sido relatados em sĂ©ries de casos de crianças com sĂ­ndrome de Zika congĂȘnita. O dĂ©ficit de crescimento pĂłs-natal dessas crianças parece ser diretamente proporcional ao grau de comprometimento neurolĂłgico. A etiologia Ă© multifatorial com fatores nutricionais e nĂŁo nutricionais provavelmente envolvidos. Os dados de nossa coorte mostram que a evolução do perĂ­metro cefĂĄlico Ă© dependente do valor dessa medida ao nascimento e que o crescimento pondero-estatural apresenta uma tendĂȘncia de menor peso e comprimento em crianças com microcefalia congĂȘnita e normocefĂĄlicas ao nascimento, mas com alguma anormalidade neurolĂłgica evolutiva. ConclusĂ”es: Os poucos dados existentes sugerem que em crianças com Zika congĂȘnita, o impacto sobre o crescimento serĂĄ tanto maior quanto maior for o grau de comprometimento neurolĂłgico, associado ou nĂŁo Ă  microcefalia ao nascimento. Keywords: Zika virus infection, Growth, Microcephaly, Palavras-chave: Infecção pelo Zika vĂ­rus, Crescimento, Microcefali

    Effects of Zika infection on growth

    No full text
    Objectives: To present the currently available evidence of the effects of congenital Zika virus infection on infant growth, to discuss possible intervening factors, and to describe preliminary data on this growth in a cohort of exposed children. Source of data: Non‐systematic review in PubMed, BVS, CAPES, Scopus, Web of Science, Cochrane and Google Scholar databases in the last 5 years, using the terms infection/disease by Zika virus and growth/nutrition/nutritional status/infant nutrition and nutritional needs. Additionally, the anthropometric data of the first 2.5 years of a cohort of children exposed to the Zika virus during pregnancy were reviewed. Synthesis of data: Both intrauterine growth restriction and low birth weight were reported in series of cases of children with congenital Zika syndrome. The postnatal growth deficit of these children appears to be directly proportional to the degree of neurological impairment. The etiology is multifactorial, and nutritional and non‐nutritional factors are probably involved. The data from the present cohort show that the head circumference evolution depends on this measurement at birth and that weight‐height growth has a trend toward lower weight and length in children with congenital microcephaly and normocephalic at birth who develop some neurological abnormality. Conclusions: The few existing data suggest that, in children with congenital Zika, the greater the degree of neurological impairment, the greater the impact on growth, whether or not associated with microcephaly at birth. Resumo: Objetivos: Apresentar as evidĂȘncias atualmente disponĂ­veis das repercussĂ”es da infecção congĂȘnita pelo vĂ­rus Zika no crescimento infantil, discutir possĂ­veis fatores intervenientes e descrever dados preliminares desse crescimento em uma coorte de crianças expostas. Fonte dos dados: RevisĂŁo nĂŁo sistemĂĄtica nos portais de banco de dados PubMed, BVS, Capes, Scopus, Web of Science, Cochrane e Google Scholar nos Ășltimos cinco anos, com o uso dos termos infecção/doença pelo vĂ­rus Zika e crescimento/nutrição/status nutricional/nutrição infantil e necessidades nutricionais. AlĂ©m disso, foram revistos os dados antropomĂ©tricos dos primeiros dois anos e meio de uma coorte de crianças expostas ao vĂ­rus Zika durante a gestação. SĂ­ntese dos dados: Tanto a restrição do crescimento intrauterino como o baixo peso ao nascer tĂȘm sido relatados em sĂ©ries de casos de crianças com sĂ­ndrome de Zika congĂȘnita. O dĂ©ficit de crescimento pĂłs‐natal dessas crianças parece ser diretamente proporcional ao grau de comprometimento neurolĂłgico. A etiologia Ă© multifatorial, com fatores nutricionais e nĂŁo nutricionais provavelmente envolvidos. Os dados de nossa coorte mostram que a evolução do perĂ­metro cefĂĄlico Ă© dependente do valor dessa medida ao nascimento e que o crescimento pondero‐estatural apresenta uma tendĂȘncia de menor peso e comprimento em crianças com microcefalia congĂȘnita e normocefĂĄlicas ao nascimento, mas com alguma anormalidade neurolĂłgica evolutiva. ConclusĂ”es: Os poucos dados existentes sugerem que em crianças com Zika congĂȘnita, o impacto sobre o crescimento serĂĄ tanto maior quanto maior for o grau de comprometimento neurolĂłgico, associado ou nĂŁo Ă  microcefalia ao nascimento. Keywords: Zika virus infection, Growth, Microcephaly, Palavras‐chave: Infecção pelo Zika vĂ­rus, Crescimento, Microcefali

    Fetal, neonatal, and infant outcomes associated with maternal Zika virus infection during pregnancy: A systematic review and meta-analysis.

    No full text
    The occurrence of fetal and neonatal disorders in pregnant women with Zika virus infection in the literature is not consistent. This study aims to estimate the prevalence rate of these disorders in fetuses/neonates of pregnant women with confirmed or probable infection by Zika virus. A systematic review with meta-analysis was conducted in November 2020. Cohort studies that contained primary data on the prevalence of unfavorable outcomes in fetuses or neonates of women with confirmed or probable Zika virus infection during pregnancy were included. A total of 21 cohort studies were included, with a total of 35,568 pregnant women. The meta-analysis showed that central nervous system abnormalities had the highest prevalence ratio of 0.06 (95% CI 0.03-0.09). Intracranial calcifications had a prevalence ratio of 0.01 (95% CI 0.01-0.02), and ventriculomegaly 0.01 (95% CI 0.01-0.02). The prevalence ratio of microcephaly was 0.03 (95% CI 0.02-0.05), fetal loss (miscarriage and stillbirth) was 0.04 (95% CI 0.02-0.06), Small for Gestational Age was 0.04 (95% CI 0.00-0,09), Low Birth Weight was 0.05 (95% CI 0.03-0.08) and Prematurity was 0.07 (95% CI 0.04-0.10). The positivity in RT-PCR for ZIKV performed in neonates born to infected mothers during pregnancy was 0.25 (95% CI 0.06-0.44). We also performed the meta-analysis of meta-analysis for microcephaly with the prevalence ratios from other two previously systematic reviews: 0.03 (95% CI 0.00-0.25). Our results contribute to measuring the impact of Zika virus infection during pregnancy on children's health. The continuous knowledge of this magnitude is essential for the implementation development of health initiatives and programs, in addition to promoting disease prevention, especially in the development of a vaccine for Zika virus. PROSPERO protocol registration: http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019125543
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