Induction and downregulation of oxidative stress and inflammation related genes in CRS patients vs. healthy controls.

<p>Induction and downregulation of oxidative stress and inflammation related genes in CRS patients vs. healthy controls.</p

Validation of differentially expressed genes on microarray by quantitative polymerase chain reaction.

<p>*P-value<0.05 for gene expression in patients at baseline vs. healthy controls as determined with qPCR technique; ^oP-value<0.05 for gene expression in patients at baseline vs. healthy controls as determined with microarray technique. ADRB2 adrenergic receptor, β2; CX3CR1 chemokine (C-X3-C motif) receptor 1; EGR1 early growth response 1; FOS FBJ murine osteosarcoma viral oncogene homolog; GPX3 glutathione peroxidase 3; IL8 interleukin 8; qPCR quantitative polymerase chain reaction.</p

Baseline characteristics.

<p>Values are expressed as mean ± SD, number (percentage) or median (interquartile range).</p><p>hsCRP: high sensitive C-reactive protein; ACEi: angiotension-converting enzyme inhibitor; ARB: angiotensin II receptor blocker; N.S. not significant.</p

Number of differentially expressed genes at different expression and significance levels in patients with low CRP and high CRP compared to healthy controls at baseline.

<p>Number of differentially expressed genes at different expression and significance levels in patients with low CRP and high CRP compared to healthy controls at baseline.</p

Euclidean cluster analysis for patients before and after erythropoietin treatment.

<p>Patient number and time point of sample collection (patient 1, timepoint 1 = 11; patient 1, timepoint 2 = 12, etc) are listed in order of monocyte transcriptomes similarity. The closer samples are depicted to each other, the more comparable transcriptomes are. Only the first 50 genes are depicted, the full figure is online.</p

Top 15 of induced and downregulated genes in CRS patients vs. healthy controls.

<p>Top 15 of induced and downregulated genes in CRS patients vs. healthy controls.</p