Matrix metalloproteinases (MMP) -3, -9, and their tissue inhibitors TIMP-1 and TIMP-3 in patients with Doppler sonographic cerebral vasospasm (dCVS) compared with patients without dCVS.

<p>MMP-9 (A) and MMP-3 (C) are significantly elevated in patients showing dCVS. * p<0.05, *** p<0.001.</p

Matrix metalloproteinases (MMP) -3, -9, and their tissue inhibitors TIMP-1 and TIMP-3 in patients with subarachnoid hemorrhage (SAH).

<p> MMP-9 (A) is significantly elevated in SAH patients compared to healthy controls (HC). By contrast MMP-3 (C) is significantly lower during the early phase after SAH, but increases later on. Serum levels of both tissue inhibitors (B, D) show a delayed rise in SAH patients. * p<0.05, ** p<0.01, *** p<0.001.</p

Baseline characteristics including demographic and laboratory data of the study population.

<p>dCVS: Doppler sonographic cerebral vasospasm, WFNS: World federation of neurosurgical societies, mRS: modified Rankin scale, EVD: external ventricular drainage,</p>*<p>Analysis of variance,</p>†<p>chi-square test.</p

Additional file 1 of Early acute kidney injury and transition to renal replacement therapy in critically ill patients with SARS-CoV-2 requiring veno-venous extracorporeal membrane oxygenation

Additional file 1: Table S1. Indications for initiation of RRT and RRT modalities used. Table S2. Pre-existing comorbidities. Table S3. Logistic regression model for factors associated with early AKI; Hierarchical stepwise backwards elimination of insignificant variables, change of parameter estimate > 10% = confounding variable. Table S4. Initial ECMO parameters in patients with early, late and no acute kidney injur