Caregivers' everyday moral reasoning predicts young children's aggressive, prosocial, and moral development: Evidence from ambulatory assessment

Developmental theories have proposed caregiver reactions, in particular caregivers' moral reasoning with their children, as crucial factors in children's developing morality. Yet, empirical evidence is scarce and mainly restricted to laboratory contexts. Here, we used the ambulatory assessment method to investigate how caregiver responses to moral transgressions longitudinally relate to children's emerging moral agency. On the first measurement point, mothers (N = 220) reported on nine consecutive evenings on a moral transgression of their 5- to 46-month-olds', their emotional and verbal reactions, and how in turn their child reacted. Five months later, mothers reported on their child's aggressive and prosocial (helping, sharing, comforting) behavior. Our results demonstrated that (1) caregiver reasoning supported children's sharing and comforting behavior and was related to lower levels of children's aggressive behavior half a year later, that (2) caregiver reasoning reactions supported children's negative evaluations of their own transgressions while compliance-based caregiver reactions (e.g., physical interventions, reprimands) were predictive of children's subsequent emotional distress and anger, and that (3) caregiver social conformity and reflective functioning abilities emerged as determinants of caregiver negative moral emotions. Thus, this study uses an innovative methodological approach to uncover key characteristics of caregiver moral reactions supporting the development of morality

Robin Hood or Matthew? Children’s Reasoning About Redistributive Justice in the Context of Economic Inequalities

How should one respond to ubiquitous economic inequalities? The legend Robin Hood suggests to take away from the wealthy to benefit the poor, whereas another strategy holds the opposite (Matthew effect). Here, 3- to 8-year-old children (N = 140) witnessed protagonists performing redistributions (e.g., Robin Hood, Matthew) of necessary and luxury resources between a wealthy and a poor child. Results showed that, with age, children increasingly approved of Robin Hood and increasingly disapproved of Matthew. In addition, reasoning about others’ welfare mediated the effect of age on children’s evaluation of Robin Hood, but only for necessary resources. This suggests that children regard restorative justice actions as a strategy to address social inequalities when it increases the welfare of disadvantaged agents

Longitudinal Relations Between Parental Strain, Parent-Child Relationship Quality, and Child Well-Being During the Unfolding COVID-19 Pandemic

As COVID-19 sweeps across the globe, scientists have identified children and families as possibly particularily vulnerable populations. The present study employed a developmental framework with two measurement points (the first at the peak of the lockdown restrictions (N = 2,921), the second after restrictions had been majorly loosened (N = 890)) to provide unique insights into the relations between parental strain, child well-being, and child problem behavior. Cross-lagged panel analyses revealed longitudinal effects of child well-being and problem behavior at T1 on parental strain at T2 with parent-child relationship quality as a moderator. True intraindividual change models showed that decreases in parental strain between measurement points predicted increases in child well-being and decreases in child problem behavior. Thus, the present research points to parental stress coping and child emotional adjustment as promising avenues for professionals and policy makers in their efforts to ensure child and family well-being throughout the pandemic

Children’s psychological well-being and problem behavior during the COVID-19 pandemic: An online study during the lockdown period in Germany

As COVID-19 dramatically changes human social life, restrictive lockdown periods to slow the spread of the virus have been suggested to particularly affect the psychological well-being of children and their families. To capture lockdown-related effects on a large scale, the present study used an online questionnaire completed by parents of 3-10-year-olds during the most restrictive lockdown period in Germany thus far (N = 2,672). Parents reported their stress level, their child’s well-being, and their child’s problem behaviors among others. Results showed that most parents and children experienced lockdown-related stress. Concerning children, not being able to meet with friends and family members outside the household emerged as the primary challenge. Older children (7–10 years) evidenced more emotional symptoms as well as less conduct problems and hyperactivity than younger children (3–6 years). Children’s own and their parents’ stress level, the degree to which children missed other children, and children’s age all showed to be negatively related to children’s general life satisfaction. Single parenthood and being an only child were associated with higher levels of child problems. Taken together, these findings shed light on the psychological well-being of children and their families during governmental lockdown measures, as well as on relations between children’s coping and demographic background. They have implications for possible avenues for interventions, inter alia by encouraging policies that facilitate the maintenance of social relationships and focus particularly on children from single parent families, on only children as well as on families in challenging housing situations

A Novel Radiomics-Based Tumor Volume Segmentation Algorithm for Lung Tumors in FDG-PET/CT after 3D Motion Correction-A Technical Feasibility and Stability Study

Positron emission tomography (PET) provides important additional information when applied in radiation therapy treatment planning. However, the optimal way to define tumors in PET images is still undetermined. As radiomics features are gaining more and more importance in PET image interpretation as well, we aimed to use textural features for an optimal differentiation between tumoral tissue and surrounding tissue to segment-target lesions based on three textural parameters found to be suitable in previous analysis (Kurtosis, Local Entropy and Long Zone Emphasis). Intended for use in radiation therapy planning, this algorithm was combined with a previously described motion-correction algorithm and validated in phantom data. In addition, feasibility was shown in five patients. The algorithms provided sufficient results for phantom and patient data. The stability of the results was analyzed in 20 consecutive measurements of phantom data. Results for textural feature-based algorithms were slightly worse than those of the threshold-based reference algorithm (mean standard deviation 1.2%-compared to 4.2% to 8.6%) However, the Entropy-based algorithm came the closest to the real volume of the phantom sphere of 6 ccm with a mean measured volume of 26.5 ccm. The threshold-based algorithm found a mean volume of 25.0 ccm. In conclusion, we showed a novel, radiomics-based tumor segmentation algorithm in FDG-PET with promising results in phantom studies concerning recovered lesion volume and reasonable results in stability in consecutive measurements. Segmentation based on Entropy was the most precise in comparison with sphere volume but showed the worst stability in consecutive measurements. Despite these promising results, further studies with larger patient cohorts and histopathological standards need to be performed for further validation of the presented algorithms and their applicability in clinical routines. In addition, their application in other tumor entities needs to be studied

Quantum phase transition in quantum wires controlled by an external gate

We consider electrons in a quantum wire interacting via a long-range Coulomb potential screened by a nearby gate. We focus on the quantum phase transition from a strictly one-dimensional to a quasi-one-dimensional electron liquid, that is controlled by the dimensionless parameter $n x_0$, where $n$ is the electron density and $x_0$ is the characteristic length of the transverse confining potential. If this transition occurs in the low-density limit, it can be understood as the deformation of the one-dimensional Wigner crystal to a zigzag arrangement of the electrons described by an Ising order parameter. The critical properties are governed by the charge degrees of freedom and the spin sector remains essentially decoupled. At large densities, on the other hand, the transition is triggered by the filling of a second one-dimensional subband of transverse quantization. Electrons at the bottom of the second subband interact strongly due to the diverging density of states and become impenetrable. We argue that this stabilizes the electron liquid as it suppresses pair-tunneling processes between the subbands that would otherwise lead to an instability. However, the impenetrable electrons in the second band are screened by the excitations of the first subband, so that the transition is identified as a Lifshitz transition of impenetrable polarons. We discuss the resulting phase diagram as a function of $n x_0$.Comment: 18 pages, 8 figures, minor changes, published versio

Any decline in prostate‐specific antigen levels identifies survivors scheduled for prostate‐specific membrane antigen‐directed radioligand therapy

Background Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) is increasingly incorporated in the therapeutic algorithm of patients with metastatic castration-resistant prostate cancer (mCRPC). We aimed to elucidate the predictive performance of early biochemical response for overall survival (OS). Materials and Methods In this bicentric analysis, we included 184 mCRPC patients treated with $^{177}$Lu-PSMA RLT. Response to treatment was defined as decrease in prostate-specific antigen (PSA) levels 8 weeks after the first cycle of RLT (any decline or >50% according to Prostate Cancer Working Group 3). OS of responders and nonresponders was then compared using Kaplan–Meier curves and log-rank comparison. Results A total of 114/184 patients (62.0%) showed any PSA decline (PSA response >50%, 55/184 [29.9%]). For individuals exhibiting a PSA decline >50%, OS of 19 months was significantly longer relative to nonresponders (13 months; hazard ratio of death [HR] = 0.64, 95% confidence interval [95% CI] = 0.44–0.93; p = 0.02). However, the difference was even more pronounced for any PSA decline, with an OS of 19 months in responders, but only 8 months in nonresponders (HR = 0.39, 95% CI = 0.25–0.60; p < 0.001). Conclusions In mCRPC patients scheduled for RLT, early biochemical response was tightly linked to prolonged survival, irrespective of the magnitude of PSA decline. As such, even in patients with PSA decrease of less than 50%, RLT should be continued

Computational analysis of heat shock proteins and ferroptosis-associated lncRNAs to predict prognosis in acute myeloid leukemia patients

Owing to their functional diversity in many cancers, long noncoding RNAs (lncRNAs) are receiving special attention. LncRNAs not only function as oncogenes or tumor suppressors by participating in various signaling pathways but also serve as predictive markers for various types of cancer, including acute myeloid leukemia (AML). Considering this, we investigated lncRNAs that may act as a mediator between two processes, i.e., heat shock proteins and ferroptosis, which appear to be closely related in tumorigenesis. Using a comprehensive bioinformatics approach, we identified four lncRNAs (AL138716.1, AC000120.1, AC004947.1, and LINC01547) with prognostic value in AML patients. Of interest, two of them (AC000120.1 and LINC01547) have already been reported to be AML-related, and AC004947.1 is considered to have oncogenic potential. In particular, the signature obtained showed a lower survival probability with high-risk patients, and vice versa. To our knowledge, this is the first predictive model of lncRNA that may correlate with the processes of heat shock proteins and ferroptosis in AML. Nevertheless, validation using patient samples is warranted