Visualization of co-occurring factors in rules for allergic eczema, asthma and atopic sensitization in PARSIFAL.

<p>Rule networks for (<b>A</b>-<b>B</b>) allergic eczema, (<b>C</b>-<b>D</b>) asthma and (<b>E</b>-<b>F</b>) atopic sensitization; affected and unaffected, respectively. Conditions that occur in the rules are on the outer ring, and co-occurrences of conditions in the rules are illustrated by ribbons across the circle connecting the conditions. The ribbon color indicates high (red) to low (grey) scores. The width of the edges is proportional to the number of correctly classified children.</p

Analysis methodology for factors related to childhood allergy in the epidemiologic studies BAMSE and PARSIFAL.

<p>Allergy phenotypes were modeled based on genetic and exposure data to identify (<b>A</b>) rules using gene and (<b>B</b>) gene and environment data. MCFS selected significant predictors of a phenotype, which was used to generate rules by ROSETTA. First model used 110 SNPs in BAMSE and PARSIFAL, while the second model included both genetic and exposure data in PARSIFAL, using BAMSE for validation when applicable.</p

Combinations of genetic variants and/or environmental factors in relation to allergy and asthma in PARSIFAL.

<p>Odds ratios are shown for the top-hits rules identified for (<b>A</b>) allergic eczema; affected^1-10 and unaffected^58-67 (<b>B</b>) asthma; affected^1-10 and unaffected^44-53 and (<b>C</b>) atopic sensitization; affected^1-10 and unaffected^37-46. The odds ratios were calculated for children that fulfill all conditions in the rule using all other children as reference.</p

SNP combinations with relevance for current asthma and wheeze in BAMSE and PARSIFAL.

<div><p>The combination of specific genetic variants in (<b>A</b>) <i>ORMDL3-RORA</i> increases the risk for current asthma¹, and in (<b>B</b>) <i>ORMDL3-RORA-COL29A1</i> increase the risk for wheeze². The risk for current asthma and wheeze increased with the number of risk genotypes described by corresponding rule (<b>C</b>-<b>D</b>). ORs and 95% confidence interval are shown. The major allele count is indicated for each gene below i.e. describing 0, 1 or 2 copies of the major allele. The reference category includes children who do not fulfill the rule.</p> <p>¹ IF ORMDL3_rs2305480=2[GG] AND RORA_rs17270362=1[AG] THEN current asthma.</p> <p>² IF COL29A1_rs11917356=2[AA] AND ORMDL3_rs7216389=0[TT] AND RORA_rs17270362=1[AG] THEN wheeze.</p></div