Characteristics of study participants.

<p>Data presented as means (95% confidence intervals).</p><p>P values represent sex differences assessed using an independent Student’s t-test.</p><p>Continuous cardiometabolic risk score was calculated by summing z-scores for insulin, glucose, triglycerides, negative HDL-cholesterol, blood pressure, BMI, and waist circumference for each participant.</p><p>BMI, body mass index; LPA, light intensity physical activity; MVPA, moderate-to-vigorous physical activity; TV, television; BP, blood pressure; HDL, high density lipoprotein; hs-CRP, high sensitivity C-reactive protein.</p

Associations of sedentary behavior with markers of cardiometabolic risk in girls.

<p>Model 1. Unadjusted analyses.</p><p>Model 2. Adjusted for accelerometer wear time, age, light and moderate-to-vigorous physical activity, total sedentary time (except when exposure), BMI Z-score (except when included in outcome), Tanner stage, parental income and level of education. Data are presented as beta coefficients (95% confidence intervals). n = 286.</p><p>Associations assessed using linear regression analysis.</p><p>Associations assessed using linear regression analysis. Data are presented as beta coefficients (95% confidence intervals). n = 236.</p>*<p> = p<0.05.</p><p>Fasting insulin and plasma triglycerides have been transformed using a Box-Cox transformation.</p><p>Continuous cardiometabolic risk score was calculated by summing z-scores for insulin, glucose, triglycerides, negative HDL-cholesterol, blood pressure, BMI, and waist circumference for each participant.</p><p>BMI, body mass index; HDL-C, high density lipoprotein cholesterol; hs-CRP, high sensitivity c-reactive protein; MVPA, moderate-to-vigorous physical activity; TV, television; WC, waist circumference.</p

Mortality and years of life lost by colorectal cancer attributable to physical inactivity in Brazil (1990–2015): Findings from the Global Burden of Disease Study

<div><p>Introduction</p><p>The aims of this study were to estimate all-cause and cause-specific mortality and years of life lost, investigated by disability-adjusted life-years (DALYs), due to colorectal cancer attributable to physical inactivity in Brazil and in the states; to analyze the temporal trend of these estimates over 25 years (1990–2015) compared with global estimates and according to the socioeconomic status of states of Brazil.</p><p>Methods</p><p>Databases from the Global Burden of Disease Study (GBD) for Brazil, Brazilian states and global information were used. It was estimated the total number and the age-standardized rates of deaths and DALYs for colorectal cancer attributable to physical inactivity in the years 1990 and 2015. We used the Socioeconomic Development Index (SDI).</p><p>Results</p><p>Physical inactivity was responsible for a substantial number of deaths (1990: 1,302; 2015: 119,351) and DALYs (1990: 31,121; 2015: 87,116) due to colorectal cancer in Brazil. From 1990 to 2015, the mortality and DALYs due to colorectal cancer attributable to physical inactivity increased in Brazil (0.6% and 0.6%, respectively) and decreased around the world (-0.8% and -1.1%, respectively). The Brazilian states with better socioeconomic indicators had higher rates of mortality and morbidity by colorectal cancer due to physical inactivity (p<0.01). Physical inactivity was responsible for deaths and DALYs due to colorectal cancer in Brazil.</p><p>Conclusions</p><p>Over 25 years, the Brazilian population showed more worrisome results than around the world. Actions to combat physical inactivity and greater cancer screening and treatment are urgent in the Brazilian states.</p></div

Relationship between age-standardized rate and DALYs from colorectal cancer due to physical inactivity and sociodemographic index of the Brazilian states in 1990 and 2015 according to sex.

<p>Rho: Spearman's correlation coefficient; ** p <0.01.</p

Number and age-standardized rate (per 100,000 inhabitants) of deaths from colorectal cancer due to physical inactivity globally, in Brazil, and in the Brazilian states.

<p>Number and age-standardized rate (per 100,000 inhabitants) of deaths from colorectal cancer due to physical inactivity globally, in Brazil, and in the Brazilian states.</p

Age-standardized DALYs (per 100,000 inhabitants) from colorectal cancer due to physical inactivity in males and females in the Brazilian states.

<p>Age-standardized DALYs (per 100,000 inhabitants) from colorectal cancer due to physical inactivity in males and females in the Brazilian states.</p