TLR7 stimulation induced type I and III IFN in HBECs.

<p>Graphs depict IFN-β protein [A], IFN-β mRNA [B], IFN-λ protein [C], IFN-λ1 mRNA [D] and IFN-λ2/3 mRNA [E] at 24 h following stimulation with R848. Squares represent asthmatics, circles represent non-asthmatics. * = p<0.05, ** = p<0.01, *** = p<0.001.</p

IL-8 induction following TLR stimulation in HBECs.

<p>Graphs depict IL-8 production at 8 h following stimulation with Poly I:C [A], CpG-C-ODN [B], CpG-B-ODN [C] and RNA40 [D] and at 24 h following R848 [E] and LPS [F]. Squares represent asthmatics, circles represent non-asthmatics. * = p<0.05, ** = p<0.01, *** = p<0.001.</p

TLR7 stimulation induced type I but not type III IFN in PBMCs.

<p>Graphs depict IFN-α protein production 8 h [A], 24 h [B] and 48 h [C] and IFN-β protein at 8 h [D], 24 h [E] and 48 h [F] post R848 stimulation. Squares represent asthmatics, circles represent non-asthmatics. * = p<0.05, ** = p<0.01, *** = p<0.001.</p

IL-8 induction following TLR stimulation in PBMCs.

<p>Graphs depict IL-8 production at 8 h following stimulation with PIC [A], R848 [B], LPS [C] and RNA40 [D], 24 h following PIC [E], R848 [F], CpG-C-ODN [G], CpG-B-ODN [H], LPS [I] and RNA40 [J] and 48 h following PIC [K]. Squares represent asthmatics, circles represent non-asthmatics. * = p<0.05, ** = p<0.01, *** = p<0.001.</p

IL-6 induction following TLR stimulation in PBMCs.

<p>Graphs depict IL-6 production at 8 h following stimulation with PIC [A], R848 [D], LPS [G] and LPS [K], 24 h following PIC [B], R848 [E], LPS [H] and LPS [L] and 48 h following PIC [C], R848 [F], LPS [J] and LPS [M]. Squares represent asthmatics, circles represent non-asthmatics. * = p<0.05, ** = p<0.01, *** = p<0.001.</p

TLR3 induced type I and III IFN in HBECs.

<p>Figures depict IFN-β protein [A], IFN-β mRNA [B], IFN-λ protein [C], IFN-λ1 mRNA [D] and IFN-λ2/3 mRNA [E] at 8 h following Poly I:C stimulation. Squares represent asthmatics and circles represent non-asthmatics. * = p<0.05, ** = p<0.01, *** = p<0.001.</p