Polk County Juvenile Drug Court: Recommendations for the Future

Capstone paper from 2015 spring MPA program. Instructed by Allen Zagoren.Polk County Juvenile Drug Court (“PCJDC”) has been operating since 2001, and has built a solid reputation within the state by addressing juvenile offenders with accompanying substance abuse problems. This paper examines the PCJDC with the hopes of identifying both what has made it successful and where improvements can be made to the program. Through interviews and surveys with current and former PCJDC staff and a review of current academic research, we offer some insight to best practices of similar programs and how they could be applied within the PCJDC program

An assessment of chemical contaminants in the marine sediments of southwest Puerto Rico

This report summarizes the results of a characterization of chemical contaminants in the sediments in southwest Puerto Rico. The report is part of a project to integrate various analytical specialties to assess linkages between chemical contaminants and the condition of coral reefs. In this phase of the project, over 120 chemical contaminants were analyzed in sediments collected, including a number of organic (e.g., hydrocarbons), inorganic (e.g., metals), and biological (bacterial) compounds/analytes. The report also provides a preliminary analysis of the association between sediment contaminants and coral species richness. Overall, the levels of chemical contaminants in the study area between Guanica Bay and the town of La Parguera were fairly low. At most of the sites sampled, particularly adjacent to the town of La Parguera, concentrations of organic and inorganic contaminants were below the median values from NOAA’s National Status and Trends Program, which monitors the Nation’s coastal and estuarine waters for chemical contaminants. Elevated levels of a number of contaminant classes were seen at the two sites sampled within Guanica Bay. An initial analysis of modeled PAH (hydrocarbon) data and coral species richness (reef building species) indicated a strong negative correlation between the presence of PAHs in the sediments and coral species richness. Additional work is needed to assess possible reasons for this observed pattern. (PDF contains 126 pages)

Left ventricular outcomes following multivessel PCI vs. infarct artery-only PCI in patients with acute STEMI: the Glasgow PRAMI CMR sub-study

No abstract available

Should hedge funds be regulated?

The rapid growth of the hedge fund industry has attracted increasing attention from government regulators. In the United States, for example, the Securities and Exchange Commission(SEC) voted in October 2004 to require many hedge funds to officially register with the Commission beginning in 2006. Actions such as this have led to a widening debate over whether(or to what extent) government should play a role in the development of the hedge fund industry. To address this issue, The Program on Alternative Investments at Columbia Business School's Center on Japanese Economy and Business sponsored a symposium entitled "Should Hedge Funds Be Regulated?" which was held at New York's University Club in November 2004. U.S. SEC Commissioner Harvey Goldschmid, currently on leave from Columbia Law School, delivered the keynote speech, arguing in favor of the Commission's October decision. Following Commissioner Goldschmid's address, Program Director Mark Mason moderated a panel of leading experts from the business, government, and academic communities who debated the pros and cons of government involvement in the industry. These panelists included Franklin Edwards, Arthur F. Burns Professor of Free and Competitive Enterprise at Columbia Business School; John Gaine, President of the Managed Funds Association, a leading hedge fund industry group; Sudhir Krishnamurthi, Managing Director of Rock Creek Capital, a Washington, D.C.-based fund of hedge funds; and Nobuyuki Kinoshita, Director at the Financial Services Agency of Japan.This report covers the keynote address by Commissioner Goldschmid, together with the remarks of the expert panelists and selected exchanges with the audience. Columbia Business School Dean Glenn Hubbard and Center on Japanese Economy and Business Director Hugh Patrick delivered opening remarks, which are also reproduced in this report

Human cytomegalovirus latency-associated proteins elicit immune-suppressive IL-10 producing CD4⁺ T cells.

Human cytomegalovirus (HCMV) is a widely prevalent human herpesvirus, which, after primary infection, persists in the host for life. In healthy individuals, the virus is well controlled by the HCMV-specific T cell response. A key feature of this persistence, in the face of a normally robust host immune response, is the establishment of viral latency. In contrast to lytic infection, which is characterised by extensive viral gene expression and virus production, long-term latency in cells of the myeloid lineage is characterised by highly restricted expression of viral genes, including UL138 and LUNA. Here we report that both UL138 and LUNA-specific T cells were detectable directly ex vivo in healthy HCMV seropositive subjects and that this response is principally CD4⁺ T cell mediated. These UL138-specific CD4⁺ T cells are able to mediate MHC class II restricted cytotoxicity and, importantly, show IFNγ effector function in the context of both lytic and latent infection. Furthermore, in contrast to CDCD4⁺ T cells specific to antigens expressed solely during lytic infection, both the UL138 and LUNA-specific CD4⁺ T cell responses included CD4⁺ T cells that secreted the immunosuppressive cytokine cIL-10. We also show that cIL-10 expressing CD4⁺ T-cells are directed against latently expressed US28 and UL111A. Taken together, our data show that latency-associated gene products of HCMV generate CD4⁺ T cell responses in vivo, which are able to elicit effector function in response to both lytic and latently infected cells. Importantly and in contrast to CD4⁺ T cell populations, which recognise antigens solely expressed during lytic infection, include a subset of cells that secrete the immunosuppressive cytokine cIL-10. This suggests that HCMV skews the T cell responses to latency-associated antigens to one that is overall suppressive in order to sustain latent carriage in vivo

Infarct size and left ventricular remodelling after preventive percutaneous coronary intervention

Objective: We hypothesised that, compared with culprit-only primary percutaneous coronary intervention (PCI), additional preventive PCI in selected patients with ST-elevation myocardial infarction with multivessel disease would not be associated with iatrogenic myocardial infarction, and would be associated with reductions in left ventricular (LV) volumes in the longer term. Methods: In the preventive angioplasty in myocardial infarction trial (PRAMI; ISRCTN73028481), cardiac magnetic resonance (CMR) was prespecified in two centres and performed (median, IQR) 3 (1, 5) and 209 (189, 957) days after primary PCI. Results: From 219 enrolled patients in two sites, 84% underwent CMR. 42 (50%) were randomised to culprit-artery-only PCI and 42 (50%) were randomised to preventive PCI. Follow-up CMR scans were available in 72 (86%) patients. There were two (4.8%) cases of procedure-related myocardial infarction in the preventive PCI group. The culprit-artery-only group had a higher proportion of anterior myocardial infarctions (MIs) (55% vs 24%). Infarct sizes (% LV mass) at baseline and follow-up were similar. At follow-up, there was no difference in LV ejection fraction (%, median (IQR), (culprit-artery-only PCI vs preventive PCI) 51.7 (42.9, 60.2) vs 54.4 (49.3, 62.8), p=0.23), LV end-diastolic volume (mL/m2, 69.3 (59.4, 79.9) vs 66.1 (54.7, 73.7), p=0.48) and LV end-systolic volume (mL/m2, 31.8 (24.4, 43.0) vs 30.7 (23.0, 36.3), p=0.20). Non-culprit angiographic lesions had low-risk Syntax scores and 47% had non-complex characteristics. Conclusions: Compared with culprit-only PCI, non-infarct-artery MI in the preventive PCI strategy was uncommon and LV volumes and ejection fraction were similar

Sagittarius A* Small Satellite Mission: Capabilities and Commissioning Preview

SSCI is leading a Defense Advanced Research Projects Agency (DARPA)-funded team launching a mission in June 2021, dubbed Sagittarius A*, to demonstrate key hardware and software technologies for on-orbit autonomy, to provide a software testbed for on-orbit developmental test & autonomous mission operations, and to reduce risk for future constellation-level mission autonomy and operations. In this paper, we present the system CONOPs and capabilities, system architectures, flight and ground software development status, and initial commissioning status. The system will fly on Loft Orbital’s YAM-3 shared LEO satellite mission, and includes SSCI’s onboard autonomy software suite running on an Innoflight CFC-400 processor with onboard Automatic Target Recognition (ATR). The autonomy payload has attitude control authority over the spacecraft bus and command authority of the imaging payload, and performs fully-autonomous onboard request handling, resource & task allocation, collection execution, ATR, and detection downlinking. The system is capable of machine-to -machine tip-and-cue from offboard cueing sources via cloud-based integrations. Requests for mission data are submitted to the satellite throughout its orbit from a tactical user level via a smartphone application, and ISR data products are downlinked and displayed at the tactical level on an Android Tactical Assault Kit (ATAK) smartphone. Follow-on software updates can be sent to the autonomy suite as over-the-air updates for on-orbit testing at any time during the on-orbit life of the satellite. Communications include GlobalStar inter-satellite communications for low rate task and status monitoring, and ground station links for payload data downloads. Planned demonstrations and opportunities will be discussed

SDSS J134441.83+204408.3: A Highly Asynchronous Short-period Magnetic Cataclysmic Variable with a 56 MG Field Strength

When the accreting white dwarf in a magnetic cataclysmic variable star (mCV) has a field strength in excess of 10 MG, it is expected to synchronize its rotational frequency to the binary orbit frequency, particularly at small binary separations, due to the steep radial dependence of the magnetic field. We report the discovery of an mCV (SDSS J134441.83+204408.3, hereafter J1344) that defies this expectation by displaying asynchronous rotation (Pspin/Porb = 0.893) in spite of a high surface field strength (B = 56 MG) and a short orbital period (114 minutes). Previously misidentified as a synchronously rotating mCV, J1344 was observed by Transiting Exoplanet Survey Satellite during sector 50, and the resulting power spectrum shows distinct spin and orbital frequencies, along with various sidebands and harmonics. Although there are several other asynchronous mCVs at short orbital periods, the presence of cyclotron humps in J1344's Sloan Digital Sky Survey spectrum makes it possible to directly measure the field strength in the cyclotron-emitting region, and while a previously study estimated 65 MG based on its identification of two cyclotron humps, we revise this to 56 ± 2 MG based on the detection of a third hump and on our modeling of the cyclotron spectrum. Short-period mCVs with field strengths above 10 MG are normally expected to be synchronous, so the highly asynchronous rotation in J1344 presents an interesting challenge for theoretical studies of spin-period evolution

Climate change alters impacts of extreme climate events on a tropical perennial tree crop

Anthropogenic climate change causes more frequent and intense fluctuations in the El Niño Southern Oscillation (ENSO). Understanding the effects of ENSO on agricultural systems is crucial for predicting and ameliorating impacts on lives and livelihoods, particularly in perennial tree crops, which may show both instantaneous and delayed responses. Using cocoa production in Ghana as a model system, we analyse the impact of ENSO on annual production and climate over the last 70 years. We report that in recent decades, El Niño years experience reductions in cocoa production followed by several years of increased production, and that this pattern has significantly shifted compared with prior to the 1980s. ENSO phase appears to affect the climate in Ghana, and over the same time period, we see corresponding significant shifts in the climatic conditions resulting from ENSO extremes, with increasing temperature and water stress. We attribute these changes to anthropogenic climate change, and our results illustrate the big data analyses necessary to improve understanding of perennial crop responses to climate change in general, and climate extremes in particular