Medical Marijuana Laws, Traffic Fatalities, and Alcohol Consumption

To date, 16 states have passed medical marijuana laws, yet very little is known about their effects. Using state-level data, we examine the relationship between medical marijuana laws and a variety of outcomes. Legalization of medical marijuana is associated with increased use of marijuana among adults, but not among minors. In addition, legalization is associated with a nearly 9 percent decrease in traffic fatalities, most likely to due to its impact on alcohol consumption. Our estimates provide strong evidence that marijuana and alcohol are substitutes.medical marijuana, traffic fatalities, alcohol consumption

High on Life? Medical Marijuana Laws and Suicide

Using state-level data for the period 1990 through 2007, we estimate the effect of legalizing medical marijuana on suicide rates. Our results suggest that the passage of a medical marijuana law is associated with an almost 5 percent reduction in the total suicide rate, an 11 percent reduction in the suicide rate of 20- through 29-year-old males, and a 9 percent reduction in the suicide rate of 30- through 39-year-old males. Estimates of the relationship between legalization and female suicides are less precise and are sensitive to functional form.medical marijuana laws, marijuana, alcohol, suicide

Per se drugged driving laws and traffic fatalities

The Office of National Drug Control Policy (ONDCP) recently announced a goal of reducing drugged driving by 10 percent within three years. In an effort to achieve this goal, ONDCP is encouraging all states to adopt per se drugged driving laws, which make it illegal to operate a motor vehicle with a controlled substance in the system. To date, 16 states have passed per se drugged driving laws, yet little is known about their effectiveness. The current study examines the relationship between these laws and traffic fatalities, the leading cause of death among Americans ages 5 through 34. Our results provide no evidence that per se drugged driving laws reduce traffic fatalities

Deployments, Combat Exposure, and Crime

During the period 2001-2009, four combat brigades and the 3rd Armored Cavalry Regiment were based at Fort Carson, Colorado. These units were repeatedly deployed during the Iraq War, allowing us to measure the effect of arguably exogenous changes in troop levels on violent crime in El Paso County, where Fort Carson is located. Our results suggest that never-deployed units contributed to community violence in the form of assaults, murders, and robberies. In contrast, estimates of the relationship between the number of previously deployed units and violent crime are generally small and statistically insignificant. We conclude that soldiers returning from combat do not represent a special threat to public safety

Medical marijuana laws, traffic fatalities, and alcohol consumption

To date, 16 states have passed medical marijuana laws, yet very little is known about their effects. Using state-level data, we examine the relationship between medical marijuana laws and a variety of outcomes. Legalization of medical marijuana is associated with increased use of marijuana among adults, but not among minors. In addition, legalization is associated with a nearly 9 percent decrease in traffic fatalities, most likely to due to its impact on alcohol consumption. Our estimates provide strong evidence that marijuana and alcohol are substitutes

The Principle of Symmetric Criticality in General Relativity

We consider a version of Palais' Principle of Symmetric Criticality (PSC) that is applicable to the Lie symmetry reduction of Lagrangian field theories. PSC asserts that, given a group action, for any group-invariant Lagrangian the equations obtained by restriction of Euler-Lagrange equations to group-invariant fields are equivalent to the Euler-Lagrange equations of a canonically defined, symmetry-reduced Lagrangian. We investigate the validity of PSC for local gravitational theories built from a metric. It is shown that there are two independent conditions which must be satisfied for PSC to be valid. One of these conditions, obtained previously in the context of transverse symmetry group actions, provides a generalization of the well-known unimodularity condition that arises in spatially homogeneous cosmological models. The other condition seems to be new. The conditions that determine the validity of PSC are equivalent to pointwise conditions on the group action alone. These results are illustrated with a variety of examples from general relativity. It is straightforward to generalize all of our results to any relativistic field theory.Comment: 46 pages, Plain TeX, references added in revised versio

Wet Laws, Drinking Establishments, and Violent Crime

Drawing on county-level data from Kansas for the period 1977-2011, we examine whether plausibly exogenous increases in the number of establishments licensed to sell alcohol by the drink are related to violent crime. During this period, 86 out of 105 counties in Kansas voted to legalize the sale of alcohol to the general public for on-premises consumption. We provide evidence that these counties experienced substantial increases in the total number of establishments with on-premises liquor licenses (e.g., bars and restaurants). Using legalization as an instrument, we show that a 10 percent increase in drinking establishments is associated with a 4 percent increase in violent crime. Reduced-form estimates suggest that legalizing the sale of alcohol to the general public for on-premises consumption is associated with an 11 percent increase in violent crime

Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the G{alpha}q/11 pathway

MrgA1 and MrgC11 belong to a recently identified family of orphan G-protein coupled receptors, called mrgs (mas-related genes). They are only expressed in a specific subset of sensory neurons that are known to detect painful stimuli. However, the precise physiological function of Mrg receptors and their underlying mechanisms of signal transduction are not known. We therefore have screened a series of neuropeptides against human embryonic kidney (HEK) 293 cells that stably express either MrgA1 or MrgC11 to identify ligands and/or agonists. MrgA1- or MrgC11-specific agonists stimulated dose-dependent increases in intracellular free Ca2+ in a pertussis toxin-insensitive manner, but failed to alter basal or forskolin-stimulated levels of intracellular cAMP. Furthermore, studies using embryonic fibroblasts derived from various G{alpha} protein knockout mice demonstrated that both the MrgA1 and MrgC11 receptors are coupled to the G{alpha}q/11 signaling pathway. Screening of neuropeptides identified surrogate agonists, most of these peptides included a common C-terminal -RF(Y)G or -RF(Y) amide motif. Structure-function studies suggest that endogenous ligands of Mrg receptors are likely to be RF(Y)G and/or RF(Y) amide-related peptides and that postprocessing of these peptides may serve to determine Mrg receptor-ligand specificity. The differences in ligand specificity also suggest functional diversity amongst the Mrg receptors

The Arches Cluster: Extended Structure and Tidal Radius

At a projected distance of ~26 pc from Sgr A*, the Arches cluster provides insight to star formation in the extreme Galactic Center (GC) environment. Despite its importance, many key properties such as the cluster's internal structure and orbital history are not well known. We present an astrometric and photometric study of the outer region of the Arches cluster (R > 6.25") using HST WFC3IR. Using proper motions we calculate membership probabilities for stars down to F153M = 20 mag (~2.5 M_sun) over a 120" x 120" field of view, an area 144 times larger than previous astrometric studies of the cluster. We construct the radial profile of the Arches to a radius of 75" (~3 pc at 8 kpc), which can be well described by a single power law. From this profile we place a 3-sigma lower limit of 2.8 pc on the observed tidal radius, which is larger than the predicted tidal radius (1 - 2.5 pc). Evidence of mass segregation is observed throughout the cluster and no tidal tail structures are apparent along the orbital path. The absence of breaks in the profile suggests that the Arches has not likely experienced its closest approach to the GC between ~0.2 - 1 Myr ago. If accurate, this constraint indicates that the cluster is on a prograde orbit and is located front of the sky plane that intersects Sgr A*. However, further simulations of clusters in the GC potential are required to interpret the observed profile with more confidence.Comment: 24 pages (17-page main text, 7-page appendix), 24 figures, accepted to Ap

High on life? Medical marijuana laws and suicide

Using state-level data for the period 1990 through 2007, we estimate the effect of legalizing medical marijuana on suicide rates. Our results suggest that the passage of a medical marijuana law is associated with an almost 5 percent reduction in the total suicide rate, an 11 percent reduction in the suicide rate of 20- through 29-year-old males, and a 9 percent reduction in the suicide rate of 30- through 39-year-old males. Estimates of the relationship between legalization and female suicides are less precise and are sensitive to functional form