Characteristics of the study participants (n = 713).

<p>*based on 654 people</p><p>^†based on 680 people</p><p>Characteristics of the study participants (n = 713).</p

Results of regression analyses of measures of atherosclerosis in the carotid and peripheral arteries in relation to intelligence in childhood.

<p>Results of regression analyses of measures of atherosclerosis in the carotid and peripheral arteries in relation to intelligence in childhood.</p

Correlations between intelligence at age 11 years and measures of atherosclerosis at age 73.

<p>Correlations between intelligence at age 11 years and measures of atherosclerosis at age 73.</p

Scatterplots of physical function against brain volumetric parameters.

<p>Note. The scatterplots are from the final models accounting for all listed covariates, with the regression line and 95% C.I. displayed. The β and p-value are for the physical function measure, while the R² is for the overall model. The final scatterplot shows the association between change in physical function and NAWM volume (the only significant association with change in physical function), and for clarity of illustration, extreme outliers were removed; the inclusion/exclusion of outliers did not alter the regression results. Scatterplots for the Wave 2 physical function measures were similar and are not reported here. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0080386#pone.0080386.s005" target="_blank">Figures S1-S3</a> for scatterplots for the individual physical function measures (extreme outliers in the final scatterplots of these figures were retained for illustrative purposes, though their inclusion/exclusion did not alter the regression results).</p

The proportion of subjects by Fazekas visual rating score.

<p>The proportion of subjects by Fazekas visual rating score.</p

Number (%) of subjects with incidental findings (IF), WMH according to visual rating by Fazekas score and atrophy against a visual population normal for age template. Fazekas total score = sum of deep and periventricular WMH scores.

<p>Bold indicates WMH scores consistent with moderate to severe WMH and atrophy at or above the upper limit of normal for age. The scale indicates a) the summed deep (0–3) and periventricular (0–3) Fazekas scores = total WMH score of 0–6, and b) the atrophy scores where 1 = <25^th centile, 2 = 25–50^th centile, 3 = 50–75^th centile, 4 = 75–95^th centile, 5 = just above 95^th centile and 6 = considerably above the 95^th centile for age.</p

The proportion of subjects with each atrophy visual rating scores.

<p>The proportion of subjects with each atrophy visual rating scores.</p

Number of subjects with several of the same type of finding within the stroke lesion section of Table 1.

<p>Number of subjects with several of the same type of finding within the stroke lesion section of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071467#pone-0071467-t001" target="_blank">Table 1</a>.</p

Examples of incidental findings in the LBC1936: (a) pituitary adenoma, (b) giant middle cerebral artery aneurysm, (c) Lhermitte-Duclos disease and (d) pleomorphic salivary adenoma.

<p>Examples of incidental findings in the LBC1936: (a) pituitary adenoma, (b) giant middle cerebral artery aneurysm, (c) Lhermitte-Duclos disease and (d) pleomorphic salivary adenoma.</p

MRI parameters at baseline and follow-up scans: uterine and fibroid volume, <i>k</i>_ep (DCE-MRI) and magnetization transfer ratio.

<p>MRI parameters at baseline and follow-up scans: uterine and fibroid volume, <i>k</i>_ep (DCE-MRI) and magnetization transfer ratio.</p