A Search for Distant Galactic Cepheids Toward l=60

We present results of a survey of a 6-square-degree region near l=60, b=0 to search for distant Milky Way Cepheids. Few MW Cepheids are known at distances >~ R_0, limiting large-scale MW disk models derived from Cepheid kinematics; this work was designed to find a sample of distant Cepheids for use in such models. The survey was conducted in the V and I bands over 8 epochs, to a limiting I~=18, with a total of ~ 5 million photometric observations of ~ 1 million stars. We present a catalog of 578 high-amplitude variables discovered in this field. Cepheid candidates were selected from this catalog on the basis of variability and color change, and observed again the following season. We confirm 10 of these candidates as Cepheids with periods from 4 to 8 days, most at distances > 3 kpc. Many of the Cepheids are heavily reddened by intervening dust, some with implied extinction A_V > 10 mag. With a future addition of infrared photometry and radial velocities, these stars alone can provide a constraint on R_0 to 8%, and in conjunction with other known Cepheids should provide good estimates of the global disk potential ellipticity.Comment: 18 pages, 4 tables, 13 figures (LaTeX / AASTeX

Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates

RNAi is a powerful method for suppressing gene expression that has tremendous potential for therapeutic applications. However, because endogenous RNAi plays a role in normal cellular functions, delivery and expression of siRNAs must be balanced with safety. Here we report successful stable expression in primates of siRNAs directed to chemokine (c-c motif) receptor 5 (CCR5) introduced through CD34+ hematopoietic stem/progenitor cell transplant. After hematopoietic reconstitution, to date 14 months after transplant, we observe stably marked lymphocytes expressing siRNAs and consistent down-regulation of chemokine (c-c motif) receptor 5 expression. The marked cells are less susceptible to simian immunodeficiency virus infection ex vivo. These studies provide a successful demonstration that siRNAs can be used together with hematopoietic stem cell transplant to stably modulate gene expression in primates and potentially treat blood diseases such as HIV-1

HST and Palomar Imaging of GRB 990123: Implications for the Nature of Gamma-Ray Bursts and their Hosts

We report on HST and Palomar optical images of the field of GRB 990123, obtained on 8 and 9 February 1999. We find that the optical transient (OT) associated with GRB 990123 is located on an irregular galaxy, with magnitude V=24.20 +/- 0.15. The strong metal absorption lines seen in the spectrum of the OT, along with the low probability of a chance superposition, lead us to conclude that this galaxy is the host of the GRB. The OT is projected within the ~1'' visible stellar field of the host, nearer the edge than the center. We cannot, on this basis, rule out the galactic nucleus as the site of the GRB, since the unusual morphology of the host may be the result of an ongoing galactic merger, but our demonstration that this host galaxy has extremely blue optical to infrared colors more strongly supports an association between GRBs and star formation. We find that the OT magnitude on 1999 Feb 9.05, V = 25.45 +/- 0.15, is about 1.5 mag fainter than expected from extrapolation of the decay rate found in earlier observations. A detailed analysis of the OT light curve suggests that its fading has gone through three distinct phases: an early rapid decline (f_{nu} \propto t^{-1.6} for t < 0.1 days), a slower intermediate decline power-law decay (f_{nu} \propto t^{-1.1} for 0.1 < t < 2 days), and then a more rapid decay (at least as steep as (f_{\nu} \propto t^{-1.8} for t > 2 days). The break to steeper slope at late times may provide evidence that the optical emission from this GRB was highly beamed.Comment: Accepted for publication in Astrophysical Journal (Letters). Fourteen pages. Three encapsulated figure

Position Statement Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus

Background: Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. Approach: An expert committee compiled evidence-based recommendations for the use of laboratory analysis in patients with diabetes. A new system was developed to grade the overall quality of the evidence and the strength of the recommendations. A draft of the guidelines was posted on the Internet, and the document was modified in response to comments. The guidelines were reviewed by the joint Evidence-Based Laboratory Medicine Committee of the AACC and the National Academy of Clinical Biochemistry and were accepted after revisions by the Professional Practice Committee and subsequent approval by the Executive Committee of the American Diabetes Association. Content: In addition to the long-standing criteria based on measurement of venous plasma glucose, diabetes can be diagnosed by demonstrating increased hemoglobin A1c (HbA1c) concentrations in the blood. Monitoring of glycemic control is performed by the patients measuring their own plasma or blood glucose with meters and by laboratory analysis of HbA1c. The potential roles of noninvasive glucose monitoring, genetic testing, and measurement of autoantibodies, urine albumin, insulin, proinsulin, C-peptide, and other analytes are addressed. Summary: The guidelines provide specific recommendations based on published data or derived from expert consensus. Several analytes are found to have minimal clinical value at the present time, and measurement of them is not recommended

The Fading Optical Counterpart of GRB~970228, Six Months and One Year Later

We report on observations of the fading optical counterpart of the gamma-ray burst GRB 970228, made with the Hubble Space Telescope STIS CCD approximately six months after outburst and with the HST/NICMOS and Keck/NIRC approximately one year after outburst. The unresolved counterpart is detected by STIS at V=28.0 +/- 0.25, consistent with a continued power-law decline with exponent -1.14 +/- 0.05. The counterpart is located within, but near the edge of, a faint extended source with diameter ~0."8 and integrated magnitude V=25.8 +/- 0.25. A reanalysis of HST and NTT observations performed shortly after the burst shows no evidence of proper motion of the point source or fading of the extended emission. Only the extended source is visible in the NICMOS images with a magnitude of H=23.3 +/- 0.1. The Keck observations find K = 22.8 +/- 0.3. Several distinct and independent means of deriving the foreground extinction in the direction of GRB 970228 all agree with A_V = 0.75 +/- 0.2. After adjusting for Galactic extinction, we find that the size of the observed extended emission is consistent with that of galaxies of comparable magnitude found in the Hubble Deep Field (HDF) and other deep HST images. Only 2% of the sky is covered by galaxies of similar or greater surface brightness; therefore the extended source is almost certainly the host galaxy. Additionally, we find that the extinction-corrected V - H and V - K colors of the host are as blue as any galaxy of comparable or brighter magnitude in the HDF. Taken in concert with recent observations of GRB 970508, GRB 971214, and GRB 980703 our work suggests that all four GRBs with spectroscopic identification or deep multicolor broad-band imaging of the host lie in rapidly star-forming galaxies.Comment: 24 pages, Latex, 4 PostScript figures, to appear in the May 10 issue of The Astrophysical Journal (Note: displayed abstract is abridged

Moons Are Planets: Scientific Usefulness Versus Cultural Teleology in the Taxonomy of Planetary Science

We argue that taxonomical concept development is vital for planetary science as in all branches of science, but its importance has been obscured by unique historical developments. The literature shows that the concept of planet developed by scientists during the Copernican Revolution was theory-laden and pragmatic for science. It included both primaries and satellites as planets due to their common intrinsic, geological characteristics. About two centuries later the non-scientific public had just adopted heliocentrism and was motivated to preserve elements of geocentrism including teleology and the assumptions of astrology. This motivated development of a folk concept of planet that contradicted the scientific view. The folk taxonomy was based on what an object orbits, making satellites out to be non-planets and ignoring most asteroids. Astronomers continued to keep primaries and moons classed together as planets and continued teaching that taxonomy until the 1920s. The astronomical community lost interest in planets ca. 1910 to 1955 and during that period complacently accepted the folk concept. Enough time has now elapsed so that modern astronomers forgot this history and rewrote it to claim that the folk taxonomy is the one that was created by the Copernican scientists. Starting ca. 1960 when spacecraft missions were developed to send back detailed new data, there was an explosion of publishing about planets including the satellites, leading to revival of the Copernican planet concept. We present evidence that taxonomical alignment with geological complexity is the most useful scientific taxonomy for planets. It is this complexity of both primary and secondary planets that is a key part of the chain of origins for life in the cosmos.Comment: 68 pages, 16 figures. For supplemental data files, see https://www.philipmetzger.com/moons_are_planets

A blue ring nebula from a stellar merger several thousand years ago

Stellar mergers are a brief but common phase in the evolution of binary star systems. These events have many astrophysical implications; for example, they may lead to the creation of atypical stars (such as magnetic stars, blue stragglers and rapid rotators), they play an important part in our interpretation of stellar populations and they represent formation channels of compact-object mergers. Although a handful of stellar mergers have been observed directly, the central remnants of these events were shrouded by an opaque shell of dust and molecules, making it impossible to observe their final state (for example, as a single merged star or a tighter, surviving binary). Here we report observations of an unusual, ring-shaped ultraviolet (‘blue’) nebula and the star at its centre, TYC 2597-735-1. The nebula has two opposing fronts, suggesting a bipolar outflow of material from TYC 2597-735-1. The spectrum of TYC 2597-735-1 and its proximity to the Galactic plane suggest that it is an old star, yet it has abnormally low surface gravity and a detectable long-term luminosity decay, which is uncharacteristic for its evolutionary stage. TYC 2597-735-1 also exhibits Hα emission, radial-velocity variations, enhanced ultraviolet radiation and excess infrared emission—signatures of dusty circumstellar disks, stellar activity and accretion. Combined with stellar evolution models, the observations suggest that TYC 2597-735-1 merged with a lower-mass companion several thousand years ago. TYC 2597-735-1 provides a look at an unobstructed stellar merger at an evolutionary stage between its dynamic onset and the theorized final equilibrium state, enabling the direct study of the merging process

Optical and Near Infrared Observations of the Afterglow of GRB 980329 from 15 Hours to 10 Days

We report I-band observations of the GRB 980329 field made on March 29 with the 1.34-m Tautenberg Schmidt telescope, R-, J- and K-band observations made on April 1 with the APO 3.5-m telescope, R- and I-band observations made on April 3 with the Mayall 4-m telescope at KPNO, and J- and K-band observations made between April 6 - 8 with the Keck-I 10-m telescope. We show that these and other reported measurements are consistent with a power-law fading of the optical/near infrared source that is coincident with the variable radio source VLA J0702+3850. This firmly establishes that this source is the afterglow of GRB 980329.Comment: Accepted to The Astrophysical Journal, 18 pages, LaTe