3 research outputs found
DS1_JVDI_10.1177_1040638718789226 – Supplemental material for Necrotizing interstitial pneumonia and suppurative myocarditis associated with <i>Bartonella henselae</i> infection in three Florida pumas
<p>Supplemental material, DS1_JVDI_10.1177_1040638718789226 for Necrotizing interstitial pneumonia and suppurative myocarditis associated with Bartonella henselae infection in three Florida pumas by Elizabeth J. Elsmo, Heather Fenton, Christopher A. Cleveland, Barbara Shock, Mark Cunningham, Elizabeth W. Howerth and Michael J. Yabsley in Journal of Veterinary Diagnostic Investigation</p
Presentation_1_Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer.PDF
<p>Agents targeting the PD1–PDL1 axis have transformed cancer therapy. Factors that influence clinical response to PD1–PDL1 inhibitors include tumor mutational burden, immune infiltration of the tumor, and local PDL1 expression. To identify peripheral correlates of the anti-tumor immune response in the absence of checkpoint blockade, we performed a retrospective study of circulating T cell subpopulations and matched tumor gene expression in melanoma and non-small cell lung cancer (NSCLC) patients. Notably, both melanoma and NSCLC patients whose tumors exhibited increased inflammatory gene transcripts presented high CD4<sup>+</sup> and CD8<sup>+</sup> central memory T cell (CM) to effector T cell (Eff) ratios in blood. Consequently, we evaluated CM/Eff T cell ratios in a second cohort of NSCLC. The data showed that high CM/Eff T cell ratios correlated with increased tumor PDL1 expression. Furthermore, of the 22 patients within this NSCLC cohort who received nivolumab, those with high CM/Eff T cell ratios, had longer progression-free survival (PFS) (median survival: 91 vs. 215 days). These findings show that by providing a window into the state of the immune system, peripheral T cell subpopulations inform about the state of the anti-tumor immune response and identify potential blood biomarkers of clinical response to checkpoint inhibitors in melanoma and NSCLC.</p
Improving the Pharmacokinetic and CYP Inhibition Profiles of Azaxanthene-Based Glucocorticoid Receptor ModulatorsIdentification of (<i>S</i>)‑5-(2-(9-Fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)‑5<i>H</i>‑chromeno[2,3‑<i>b</i>]pyridin-5-yl)-2-methylpropanamido)‑<i>N</i>‑(tetrahydro‑2<i>H</i>‑pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341)
An
empirical approach to improve the microsomal stability and CYP
inhibition profile of lead compounds <b>1a</b> and <b>1b</b> led to the identification of <b>5</b> (BMS-341) as a dissociated
glucocorticoid receptor modulator. Compound <b>5</b> showed
significant improvements in pharmacokinetic properties and, unlike
compounds <b>1a</b>–<b>b</b>, displayed a linear,
dose-dependent pharmacokinetic profile in rats. When tested in a chronic
model of adjuvant-induced arthritis in rat, the ED<sub>50</sub> of <b>5</b> (0.9 mg/kg) was superior to that of both <b>1a</b> and <b>1b</b> (8 and 17 mg/kg, respectively)