Correlations of Extraversion and volume in the OFC and amygdala.

<p>A) Positive correlation of extraversion and volume of the right orbital frontal gyrus scaled for total gray matter volume (r = .33; r_partial = .47 when neuroticism and age were partialled out) . B) Positive correlation of extraversion and right amygdala volume scaled for total gray matter volume (r = .31, r_partial = .39 when neuroticism and age were partialled out). Mean volume in ml of the significant voxels was extracted per subject and divided by total GM volume. In the correlation plots, mean volume of the significant amygdala and ofc region is depicted in scaled volume in ml * 10⁻³.</p

VBM effects.

<p>R/L: Right vs. Left hemisphere; BA: Brodmann area; k = clustersize at p<.001, uncorrected; r = correlation coefficient at peak voxel.</p

PC-MRI for quantification of total CBF.

<p>(a) A PC-MRI scan for measuring mean tCBF was prescribed on a PC-MRI sagittal localizer image perpendicular to the carotid arteries at the level of the mid basilar artery. (b) A representative phase image demonstrating the right and left internal carotid arteries (R.ICA and L.ICA) together with the basilar artery (BA).</p

Voxel-based assessment of age-related changes of white matter magnetization transfer ratio (MTR).

<p>Fig. 1 shows results from the voxel-based assessment of age-related changes of white matter magnetization transfer ratio (MTR) in the whole study population using FSL-TBSS. Results are projected on the mean fractional anisotropy (FA) image of the whole study population which is derived from a diffusion tensor imaging (DTI) scan sequence. The mean white matter skeleton of the whole study population is shown in green color. Red color shows areas of statistically significant decrease of white matter MTR with increasing chronological age (p < 0.05).</p

Characteristics of the study population.

<p>SD, standard deviation</p><p>Characteristics of the study population.</p

Association of MTI parameters of subcortical gray matter structures with chronological age.

<p>Values represent standardized Betas. P-values (p) are adjusted for sex and affiliation to the offspring or control group.</p><p>MTR, magnetization transfer ratio</p><p>Association of MTI parameters of subcortical gray matter structures with chronological age.</p

Representative CBF maps of one study participant.

<p>Representative CBF maps of an 80 year old male participant with whole brain CBF 47.6 and 49.5 ml/100g/min for the first and second scan at rest respectively. (a) First row corresponds to first scan at rest and (b) second row to rescan at rest.</p

Comparison of CBF values at rest and activation.

<p>(a) Average CBF maps of the entire study sample (n = 17) of the first scan at rest (Rest 1), rescan at rest (Rest 2) and at activation by bilateral finger-tapping (activation). (b) Comparison of CBF values at rest and activation by finger-tapping on a voxel level showed significantly higher perfusion during activation in the motor and somatosensory regions at threshold p≤0.01.</p

Agreement between scans at rest for whole brain CBF.

<p>Bland-Altman plot demonstrating the agreement between the first and second scan at rest for whole brain CBF. Solid mid and upper-lower lines are the mean bias and limits of agreement (1.96 standard deviation), respectively. Y-axis displays mean difference between first and second scan and x-axis the average CBF of the first and second scan.</p

Association of MTI parameters of cortical gray matter and white matter with chronological age.

<p>Values represent standardized Betas. P-values (p) are adjusted for sex and affiliation to the offspring or control group.</p><p>MTR, magnetization transfer ratio</p><p>Association of MTI parameters of cortical gray matter and white matter with chronological age.</p