Nanotechnology and cancer

The biological picture of cancer is rapidly advancing from models built from phenomenological descriptions to network models derived from systems biology, which can capture the evolving pathophysiology of the disease at the molecular level. The translation of this (still academic) picture into a clinically relevant framework can be enabling for the war on cancer, but it is a scientific and technological challenge. In this review, we discuss emerging in vitro diagnostic technologies and therapeutic approaches that are being developed to handle this challenge. Our discussion of in vitro diagnostics is guided by the theme of making large numbers of measurements accurately, sensitively, and at very low cost. We discuss diagnostic approaches based on microfluidics and nanotechnology. We then review the current state of the art of nanoparticle-based therapeutics that have reached the clinic. The goal of the presentation is to identify nanotherapeutic strategies that are designed to increase efficacy while simultaneously minimizing the toxic side effects commonly associated with cancer chemotherapies

Effects of Neighborhood Characteristics on the Mortality of Black Male Youth: Evidence From Gautreaux

The Gautreaux data for this paper were created with the assistance of the Leadership Council for Metropolitan Open Communities under special agreement with the U.S. Department of Housing and Urban Development and the National Center for Health Statistics. Generous support for data construction and analysis was provided by Daniel Rose and the MIT Center for Real Estate, the National Bureau of Economic Research, the National Science Foundation (SBE-9876337), the Princeton Center for Economic Policy Studies, and the Princeton Industrial Relations Section. Technical support was provided by the Princeton Office of Population Research (NICHD 5P30-HD32030) and the Princeton Center for Health and Wellbeing. Mortality count data for male youth residing in Chicago community areas were graciously provided by the Illinois Center for Health Statistics. We thank Greg Duncan and members of the Princeton Industrial Relations Section for helpful comments.Neighborhood effects; Mortality

Effects of Neighborhood Characteristics on the Mortality of Black Male Youth: Evidence From Gautreaux

neighborhood effects, mortality

Gamma-Ray Bursts and the Cosmic Star Formation Rate

We have tested several models of GRB luminosity and redshift distribution functions for compatibility with the BATSE 4B number versus peak flux relation. Our results disagree with recent claims that current GRB observations can be used to strongly constrain the cosmic star formation history. Instead, we find that relaxing the assumption that GRBs are standard candles renders a very broad range of models consistent with the BATSE number-flux relation. We explicitly construct two sample distributions, one tracing the star formation history and one with a constant comoving density. We show that both distributions are compatible with the observed fluxes and redshifts of the bursts GRB970508, GRB971214, and GRB980703, and we discuss the measurements required to distinguish the two models.Comment: 12 pages, 2 postscript figures, uses AAS LaTex macros v4.0. To be published in Astrophysical Journal Letters, accepted August 20, 1998. Revised for publicatio

Gamma-Ray Observations of GRO J1655-40

The bright transient X-ray source GRO J1655-40 = XN Sco 1994 was observed by the OSSE instrument on the Compton Gamma Ray Observatory (GRO). Preliminary results are reported here. The initial outburst from GRO J1655-40 was detected by BATSE on 27 Jul 1994. OSSE observations were made in five separate viewing periods starting between 4 Aug 1994 and 4 Apr 1995. The first, third, and fifth observations are near the peak luminosity. In the second observation, the source flux had dropped by several orders of magnitude and we can only set an upper limit. The fourth observation is a weak detection after the period of maximum outburst. In contrast with other X-ray novae such as GRO J0422+32, the spectrum determined by OSSE is consistent with a simple power law over the full range of detection, about 50 - 600 keV. The photon spectral index is in the range of -2.5 to 2.8 in all of the observations. We set an upper limit on fractional rms variation \u3c5% in the frequency range 0.01 – 60 Hz. No significant narrow or broad line features are observed at any energy