Achieving high cancer control trial enrollment in the community setting: An analysis of the Community Clinical Oncology Program

Determining the factors that lead to successful enrollment of patients in cancer control clinical trials is essential as cancer patients are often burdened with side effects such as pain, nausea, and fatigue. One promising intervention for increasing enrollment in cancer control trials is the National Cancer Institute’s Community Clinical Oncology Program (CCOP). In this article, we examined CCOP staffing, polices, and procedures associated with enrollment in control trials. Data were obtained from three sources: the online CCOP, MB-CCOP, and Research Base Management System, CCOP Annual Progress Reports, and a survey of CCOP Administrators conducted in 2011. We analyzed cancer control trial accrual in 2011 among 46 CCOPs using multivariate regression. Three factors were significant predictors of accrual. First, having a team of staff dedicated to enrolling patients in control and prevention trials, compared to having no dedicated staff, was associated on average with an additional 30 patients enrolled in control trials (p <0.05). Second, CCOPs that recognized physicians for enrolling a large number of patients compared to CCOPs that did not recognize high enrolling physicians enrolled on average an additional 25 patients in control trials (p <0.05). Lastly, the number of cancer control trials available was also associated with enrollment (β = 5.50, p<0.00). Our results indicate that CCOPs looking to increase enrollment in control trials should consider dedicating a team of staff to enroll patients in these types of trials. In addition, CCOPs or other volunteer research systems looking to increase physician participation should consider recognizing high enrolling physicians

A method for analyzing the business case for provider participation in the National Cancer Institute's Community Clinical Oncology Program and similar federally funded, provider-based research networks: Analyzing the Business Case for Research

The Community Clinical Oncology Program (CCOP) plays an essential role in the National Cancer Institute’s (NCI) efforts to increase enrollment in clinical trials. There is currently little practical guidance in the literature to assist provider organizations in analyzing the return on investment (ROI), or business case, for establishing and operating a provider-based research network (PBRN) such as the CCOP. This paper presents a conceptual model of the business case for PBRN participation and provides a spreadsheet-based tool and advice for evaluating the business case for provider participation in a CCOP organization

Organizational and physician factors associated with patient enrollment in cancer clinical trials

Our purpose was to identify physicians’ individual characteristics, attitudes, and organizational contextual factors associated with higher enrollment of patients in cancer clinical trials among physician participants in the National Cancer Institute’s Community Clinical Oncology Program (CCOP). We hypothesized that physicians’ individual characteristics, such as age, medical specialty, tenure, CCOP organizational factors (i.e., policies and procedures to encourage enrollment), and attitudes towards participating in CCOP would directly determine enrollment. We also hypothesized that physicians’ characteristics and CCOP organizational factors would influence physicians’ attitudes towards participating in CCOP, which in turn would predict enrollment

Engaging Referring Physicians in the Clinical Trial Process

By building relationships with referring physicians and educating them about the clinical trial process, oncologists can help increase trial accrual among patients with cancer

Achieving high cancer control trial enrollment in the community setting: An analysis of the Community Clinical Oncology Program

Determining the factors that lead to successful enrollment of patients in cancer control clinical trials is essential as cancer patients are often burdened with side effects such as pain, nausea, and fatigue. One promising intervention for increasing enrollment in cancer control trials is the National Cancer Institute’s Community Clinical Oncology Program (CCOP). In this article, we examined CCOP staffing, polices, and procedures associated with enrollment in control trials. Data were obtained from three sources: the online CCOP, MB-CCOP, and Research Base Management System, CCOP Annual Progress Reports, and a survey of CCOP Administrators conducted in 2011. We analyzed cancer control trial accrual in 2011 among 46 CCOPs using multivariate regression. Three factors were significant predictors of accrual. First, having a team of staff dedicated to enrolling patients in control and prevention trials, compared to having no dedicated staff, was associated on average with an additional 30 patients enrolled in control trials (p <0.05). Second, CCOPs that recognized physicians for enrolling a large number of patients compared to CCOPs that did not recognize high enrolling physicians enrolled on average an additional 25 patients in control trials (p <0.05). Lastly, the number of cancer control trials available was also associated with enrollment (β = 5.50, p<0.00). Our results indicate that CCOPs looking to increase enrollment in control trials should consider dedicating a team of staff to enroll patients in these types of trials. In addition, CCOPs or other volunteer research systems looking to increase physician participation should consider recognizing high enrolling physicians