Elderly Subjects Have a Delayed Antibody Response and Prolonged Viraemia following Yellow Fever Vaccination: A Prospective Controlled Cohort Study

Yellow fever vaccination (YF-17D) can cause serious adverse events (SAEs). The mechanism of these SAEs is poorly understood. Older age has been identified as a risk factor. We tested the hypothesis that the humoral immune response to yellow fever vaccine develops more slowly in elderly than in younger subjects.We vaccinated young volunteers (18–28 yrs, N = 30) and elderly travelers (60–81 yrs, N = 28) with YF-17D and measured their neutralizing antibody titers and plasma YF-17D RNA copy numbers before vaccination and 3, 5, 10, 14 and 28 days after vaccination. = 0.02, using a mixed linear model. Viraemia was more common in the elderly (86%, 24/28) than in the younger participants (60%, 14/30) (p = 0.03) with higher YF-17D RNA copy numbers in the elderly participants.We found that elderly subjects had a delayed antibody response and higher viraemia levels after yellow fever primovaccination. We postulate that with older age, a weaker immune response to yellow fever vaccine allows the attenuated virus to cause higher viraemia levels which may increase the risk of developing SAEs. This may be one piece in the puzzle of the pathophysiology of YEL-AVD

School en ouders als partners in de opvoeding van tieners

Dit rapport gaat over betrokkenheid van migrantenouders bij de school van hun kinderen en hoe zij aankijken tegen de verhouding tussen school en thuis inzake allerlei opvoedkwesties. Door middel van literatuurstudie, gesprekken met leiding, docenten en ouders van een havo/vwo-school in Amsterdam Nieuw West is beschreven hoe ouderbetrokkenheid vorm krijgt. Aan de orde komen positieve ervaringen, belemmeringen en verbeterwensen inzake partnerschap tussen ouders en school in de opvoeding van en het onderwijs voor jongeren. En welke rol preventieve opvoedsteun daarin kan vervullen