IL-17 expression in the submucosa of bronchial biopsies of 4 groups of studied population.

<p>atopic inhaled corticosteroid (ICS) user (frame A), nonatopic ICS user (frame B), atopic non-ICS user (frame C), nonatopic non-ICS user (frame D). Single staining for IL-17 (frame E; blue) and MPO (frame F; red) and double staining for IL-17 and MPO (frame G; purple) in adjacent sections of a nonatopic non-ICS user asthmatic patient. Single staining for IL-17 (frame H; blue) and EPX (frame I; red) and double staining for IL-17 and EPX (frame J; purple) in adjacent sections of an atopic non-ICS user asthmatic patient.</p

Inflammation in atopic and nonatopic asthmatics.

<p>Inflammation in atopic and nonatopic asthmatics.</p

Positive correlation between the number of IL-17⁺ cells and neutrophils in the submucosa of bronchial biopsies from atopic (r_s = 0.44; p<0.001) and nonatopic (r_s = 0.45, p = 0.009) asthmatics (A), or from asthmatics who are inhaled corticosteroid (ICS) (r_s = 0.35; p = 0.01) and non-ICS (r_s = 0.48; p<0.0001) users (B).

<p>Positive correlation between the number of IL-17⁺ cells and neutrophils in the submucosa of bronchial biopsies from atopic (r_s = 0.44; p<0.001) and nonatopic (r_s = 0.45, p = 0.009) asthmatics (A), or from asthmatics who are inhaled corticosteroid (ICS) (r_s = 0.35; p = 0.01) and non-ICS (r_s = 0.48; p<0.0001) users (B).</p

Negative correlation between the number of IL-17⁺ cells in the submucosa of bronchial biopsies and serum specific IgE (Phadiatop) from asthmatics (rs = -0.37; P<0.001).

<p>Negative correlation between the number of IL-17⁺ cells in the submucosa of bronchial biopsies and serum specific IgE (Phadiatop) from asthmatics (rs = -0.37; P<0.001).</p

Number of IL-17⁺ cells in submucosa in bronchial biopsies from atopic and nonatopic asthmatics who are inhaled corticosteroid (ICS) users or non-ICS users.

<p>Number of IL-17⁺ cells in submucosa in bronchial biopsies from atopic and nonatopic asthmatics who are inhaled corticosteroid (ICS) users or non-ICS users.</p

Patient characteristics.

<p>Patient characteristics.</p