Supplemental Material, VRD756405_SM - Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration

<p>Supplemental Material, VRD756405_SM for Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration by Siqing Yu, Sebastian Wolf, Marion R. Munk, Martin S. Zinkernagel, and Andreas Ebneter in Journal of VitreoRetinal Diseases</p

Superficial capillary plexus.

<p>Representative en face scans of the superficial capillary plexus (SCP) using the Swept source OCT Angio Topcon DRI OCT Triton (Top left), the Angiovue Optovue RTVue XR Avanti, (Top right), the Prototype of Spectralis OCT2 module with full spectrum decorrelation algorithm, Heidelberg Engineering (Bottom left) and the Zeiss AngioPlex Cirrus 5000 HD-OCT (Bottom right).</p

Inter-grader reliability in respect to individual devices.

<p>Inter-grader reliability in respect to individual devices.</p

Deep capillary plexus.

<p>Representative en face scans of the deep capillary plexus (SCP) using the Swept source OCT Angio Topcon DRI OCT Triton (Top left), the Angiovue Optovue RTVue XR Avanti, (Top right), the Prototype of Spectralis OCT2 module with full spectrum decorrelation algorithm, Heidelberg Engineering (Bottom left) and the Zeiss AngioPlex Cirrus 5000 HD-OCT (Bottom right).</p

OCT-A module ranking.

<p>OCT-A module ranking.</p

Ranking and underlying normalized scores of each module for each evaluated variable of the consensus dataset.

<p>Ranking and underlying normalized scores of each module for each evaluated variable of the consensus dataset.</p

Severe motion artefacts.

<p>Representative examples of severe motion artefacts.</p

78 year old male with primary open angle glaucoma (POAG) with peripapillary retinoschisis.

<p>(1A) Optic nerve photograph shows glaucomatous optic neuropathy (1B) There is mild visual field damage with a mean deviation of -2.19 dB. (1C, 1D and 1E) Three horizontal OCT raster scans through three different sections of the optic nerve demonstrating peripapillary retinal splitting (retinoschisis) with adherent vitreous in the region of retinoschisis (yellow arrow), splitting in the nerve fiber layer (yellow star), and inner plexiform layer (white star) and outer plexiform layer with a likely outer nuclear layer component as well (white arrows). (1F) Circumpapillary retinal nerve fiber layer (RNFL) thickness map shows retinoschisis nasally within the RNFL segmentation (yellow star), causing a small area of artifactual thickening on the RNFL thickness profile.</p

Distribution of diagnosis in eyes with and without peripapillary retinal splitting (schisis).

<p>Distribution of diagnosis in eyes with and without peripapillary retinal splitting (schisis).</p

67 year old male with advanced POAG, with peripapillary retinochisis.

<p>(2A) Optic nerve photograph shows glaucomatous optic neuropathy. (2B) There is advanced visual field damage, with a mean deviation of -19.65 dB. (2C) OCT demonstrates peripapillary retinoschisis in the outer nuclear layer and outer plexiform layer (C; white arrows) on two horizontal raster scans through the optic nerve. (2D) Circumpapillary RNFL thickness map shows retinoschisis nasally.</p