Range expansion of Ambrosia artemisiifolia in Europe is promoted by climate change

Ambrosia artemisiifolia L., native to North America, is a problematic invasive species, because of its highly allergenic pollen. The species is expected to expand its range due to climate change. By means of ecological niche modelling (ENM), we predict habitat suitability for A. artemisiifolia in Europe under current and future climatic conditions. Overall, we compared the performance and results of 16 algorithms commonly applied in ENM. As occurrence records of invasive species may be dominated by sampling bias, we also used data from the native range. To assess the quality of the modelling approaches we assembled a new map of current occurrences of A. artemisiifolia in Europe. Our results show that ENM yields a good estimation of the potential range of A. artemisiifolia in Europe only when using the North American data. A strong sampling bias in the European Global Biodiversity Information Facility (GBIF) data for A. artemisiifolia causes unrealistic results. Using the North American data reflects the realized European distribution very well. All models predict an enlargement and a northwards shift of potential range in Central and Northern Europe during the next decades. Climate warming will lead to an increase and northwards shift of A. artemisiifolia in Europe

Inductance-based Flexible Pressure Sensor for Assistive Gloves

This paper presents an inductance-based flexible pressure sensor to support the tactile communication between deafblind people. The pressure sensor was realized with a soft ferromagnetic elastomer and a 17μm-thick coil fabricated on a 50 μm thick flexible polyimide sheet. The ferromagnetic elastomer acts as the core of the coil, which when pressed, sees the metal particles moving closer to each other and leads to changes in the inductance. The coil, with 75μm wide wires and 25μm pitch, was realized using LIGA (Lithographie Galvanoformung, Abformung) micro molding technique. Four different sensors have been fabricated using different ratios (1:1, 2:1, 3:1 and 5:1) of ecoflex and iron nanoparticles. The results show that the higher the ratio the better the response of the sensor. The presented sensor is intended to be integrated in a smart glove having dual function of tactile sensing and vibrotactile feedback

Environmental Health Makes a Strong Entry Into the Global One Health Framework in Jamaica

Globally, the environmental health discipline is rapidly being recognized as a critical science-based discipline needed for protecting human, animal, and ecological health. Such recognition and tremendous excitement were achieved as over 400 academicians and practitioners convened in October 2017 at the beautiful seaside Hilton Rose Hall Resort & Spa in Montego Bay, Jamaica, for the largest and first environmental health conference of its kind on One Health to occur worldwide

Wearable assistive tactile communication interface based on integrated touch sensors and actuators

This paper presents the design and fabrication of a wearable tactile communication interface with vibrotactile feedback for assistive communication. The interface is based on finger Braille, which is a simple and efficient tactile communication method used by deafblind people. It consists of a flexible piezoresistive sensor and a vibrotactile actuator integrated together and positioned at the index, middle and ring fingers of both hands to represent the six dots of Braille. The sensors were made using flexible piezoresistive material whereas the actuator utilizes electromagnetic principle by means of a flexible coil and a tiny NdFeB permanent magnet. Both were integrated to realize a Bluetooth-enabled tactile communication glove which enables deafblind people to communicate using Braille codes. The evaluation with 20 end-users (10 deafblind and 10 sighted and hearing person) of the tactile interface under standardized conditions demonstrated that users can feel and distinguish the vibration at frequencies ranging from 10Hz to 200Hz which is within the perceivable frequency range for the FA-II receptors. The results show that it took non-experts in Braille within 25s and 55s to send and receive words like “BEST” and “JOURNAL”, with an accuracy of ~75% and 68% respectively

Targeting the oligomerization of BCR/ABL by membrane permeable competitive peptides inhibits the proliferation of Philadelphia Chromosome positive leukemic cells

The BCR/ABL fusion protein is the hallmark of Philadelphia Chromosome positive (Ph+) leukemia. The constitutive activation of the ABL-kinase in BCR/ABL cells induces the leukemic phenotype. Targeted inhibition of BCR/ABL by small molecule inhibitors reverses the transformation potential of BCR/ABL. Recently, we definitively proved that targeting the tetramerization of BCR/ABL mediated by the N-terminal coiled-coil domain (CC) using competitive peptides, representing the helix-2 of the CC, represents a valid therapeutic approach for treating Ph+ leukemia. To further develop competitive peptides for targeting BCR/ABL, we created a membrane permeable helix-2 peptide (MPH-2) by fusing the helix-2 peptide with a peptide transduction tag. In this study, we report that the MPH-2: (i) interacted with BCR/ABL in vivo; (ii) efficiently inhibited the autophosphorylation of BCR/ABL; (iii) suppressed the growth and viability of Ph+ leukemic cells; and (iv) was efficiently transduced into mononuclear cells (MNC) in an in vivo mouse model. This study provides the first evidence that an efficient peptide transduction system facilitates the employment of competitive peptides to target the oligomerization interface of BCR/ABL in vivo

Exploring Minecraft Settlement Generators with Generative Shift Analysis

With growing interest in Procedural Content Generation (PCG) it becomes increasingly important to develop methods and tools for evaluating and comparing alternative systems. There is a particular lack regarding the evaluation of generative pipelines, where a set of generative systems work in series to make iterative changes to an artifact. We introduce a novel method called Generative Shift for evaluating the impact of individual stages in a PCG pipeline by quantifying the impact that a generative process has when it is applied to a pre-existing artifact. We explore this technique by applying it to a very rich dataset of Minecraft game maps produced by a set of alternative settlement generators developed as part of the Generative Design in Minecraft Competition (GDMC), all of which are designed to produce appropriate settlements for a pre-existing map. While this is an early exploration of this technique we find it to be a promising lens to apply to PCG evaluation, and we are optimistic about the potential of Generative Shift to be a domain-agnostic method for evaluating generative pipelines

Principles and practices of ESL teachers: A study of adults and children

The study reported here aimed to identify the particular practices and uncover the particular principles of a group of ESL teachers. Some of the teachers were working with adult learners and some were working with young children. The research aimed to answer three main questions: 1. What are the classroom practices of this group of language teachers? 2. What principles do they identify as underlying their work in the classroom? 3. What is the relationship between the principles they held and the practices they adopted? The study also aimed to find out if there were similarities or differences between teachers of adults and teachers of children in both the practices they adopted and the principles which motivated their work. In other words, we wanted to know whether teachers\u27 thinking and behaviour in the classroom were influenced by the age of the learners whom they taught. The study further aimed to consider if variation among the teachers in their practices and principles was due to the teachers\u27 professional experiences, their own language backgrounds, and the different institutional contexts in which they were teaching

Exploring Minecraft Settlement Generators with Generative Shift Analysis

© 2023 The Author(s). This is an open access conference paper distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/With growing interest in Procedural Content Generation (PCG) it becomes increasingly important to develop methods and tools for evaluating and comparing alternative systems. There is a particular lack regarding the evaluation of generative pipelines, where a set of generative systems work in series to make iterative changes to an artifact. We introduce a novel method called Generative Shift for evaluating the impact of individual stages in a PCG pipeline by quantifying the impact that a generative process has when it is applied to a pre-existing artifact. We explore this technique by applying it to a very rich dataset of Minecraft game maps produced by a set of alternative settlement generators developed as part of the Generative Design in Minecraft Competition (GDMC), all of which are designed to produce appropriate settlements for a pre-existing map. While this is an early exploration of this technique we find it to be a promising lens to apply to PCG evaluation, and we are optimistic about the potential of Generative Shift to be a domain-agnostic method for evaluating generative pipelines

Extracellular vesicles from regenerative human cardiac cells act as potent immune modulators by priming monocytes

Background: Nano-sized vesicles, so called extracellular vesicles (EVs), from regenerative cardiac cells represent a promising new therapeutic approach to treat cardiovascular diseases. However, it is not yet sufficiently understood how cardiac-derived EVs facilitate their protective effects. Therefore, we investigated the immune modulating capabilities of EVs from human cardiac-derived adherent proliferating (CardAP) cells, which are a unique cell type with proven cardioprotective features. Results: Differential centrifugation was used to isolate EVs from conditioned medium of unstimulated or cytokinestimulated (IFNγ, TNFα, IL-1β) CardAP cells. The derived EVs exhibited typical EV-enriched proteins, such as tetraspanins, and diameters mostly of exosomes (< 100 nm). The cytokine stimulation caused CardAP cells to release smaller EVs with a lower integrin ß1 surface expression, while the concentration between both CardAP-EV variants was unaffected. An exposure of either CardAP-EV variant to unstimulated human peripheral blood mononuclear cells (PBMCs) did not induce any T cell proliferation, which indicates a general low immunogenicity. In order to evaluate immune modulating properties, PBMC cultures were stimulated with either Phytohemagglutin or anti-CD3. The treatment of those PBMC cultures with either CardAP-EV variant led to a significant reduction of T cell proliferation, pro-inflammatory cytokine release (IFNγ, TNFα) and increased levels of active TGFβ. Further investigations identified CD14+ cells as major recipient cell subset of CardAP–EVs. This interaction caused a significant lower surface expression of HLA-DR, CD86, and increased expression levels of CD206 and PD-L1. Additionally, EV-primed CD14+ cells released significantly more IL-1RA. Notably, CardAP-EVs failed to modulate anti-CD3 triggered T cell proliferation and pro-inflammatory cytokine release in monocultures of purified CD3+ T cells. Subsequently, the immunosuppressive feature of CardAPEVs was restored when anti-CD3 stimulated purified CD3+ T cells were co-cultured with EV-primed CD14+ cells. Beside attenuated T cell proliferation, those cultures also exhibited a significant increased proportion of regulatory T cells. Conclusions: CardAP-EVs have useful characteristics that could contribute to enhanced regeneration in damaged cardiac tissue by limiting unwanted inflammatory processes. It was shown that the priming of CD14+ immune cells by CardAP-EVs towards a regulatory type is an essential step to attenuate significantly T cell proliferation and proinflammatory cytokine release in vitro