Additional file 1: Table S1. of Blood pressure in young adulthood and residential greenness in the early-life environment of twins

Pearson correlation coefficient between greenness in early-life and adult life. Table S2. Collinearity diagnosis. Table S3. Estimated difference in night systolic blood pressure (mm Hg) with land-use indicators at birth in all buffer sizes in twins who moved since birth. Figure S1. Ambulatory blood pressure (mm Hg) in association with residential greenness exposure with no adjustment for exposure in adulthood/early-life in twins who moved during life. Figure S2. Ambulatory blood pressure (mm Hg) in association with residential area. Figure S3. Ambulatory blood pressure (mm Hg) in association with industrial area. (DOCX 872 kb

Clinical characteristics of 195 lacunar stroke patients.

<p>Data are presented as mean ± SD or number of affected patients (%).</p

Composition of families of 195 lacunar stroke patients.

<p>Data are presented as number of patients (%). For example, 125 patients had no parent with a history of stroke.</p

Relationship of proband characteristics to family history of stroke in parents and siblings.

<p>Data are depicted as OR (95%CI). FHstroke indicates family history of stroke.</p><p>*p<0.05</p

Genetic Relative Risk (GRR) compared to general population of Rotterdam (see text).

<p>Figures are numbers of known and affected family-members (%) and genetic relative risk (with 95% CI). FDR indicates first-degree relatives.</p

MOESM1 of Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner

Supplementary material 1 (PDF 158 kb

Regression Coefficients for Δ Birth Weight in MZ and DZ twins (Pair Wise, Stratified Analysis).

<p>Results were obtained by use of a two-level random intercept, random slope (for time) model.</p><p>Model 1: Δ birth weight and time point.</p><p>Model 2: model 1+chorionicity, Δ physical activity, Δ height and Δ weight (the latter not included in the V02 peak models).</p><p>MZ: Monozygotic, DZ: Dizygotic.</p

Regression Coefficients for Birth Weight in the Individual Analysis.

<p>Results were obtained by use of a three-level random intercept, random slope (for time) model.</p><p>Model 1: birth weight, gestational age, time point and sex.</p><p>Model 2: model 1+zygosity-chorionicity, smoking, physical activity, height and weight (the latter not included in the V02 peak models).</p><p>Model 3: model 2+parental BMI.</p

Average maximum oxygen uptake in birth weight quarters.

<p>Q1–Q4: Birth weight quarter 1–4 (Q1 = lowest quarter).</p

Regression Coefficients for Birth Weight: Mean of the Twin Pair and Difference within the Twin Pair.

<p>Results were obtained by use of a three-level random intercept, random slope (for time) model.</p><p>Model: birth weight, gestational age, time point, sex, zygosity-chorionicity, smoking, physical activity, height, weight (not included in the V02 peak models) and parental BMI.</p