30 research outputs found
Supplementary Figure 6 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Abrogation of SHH signaling fuels hypersprouting in human and murine PDAC explants.</p
Supplementary Figure 4 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Explant cellular populations throughout culture.</p
Supplementary Figure 5 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
SHH secretion in vitro and ex vivo.</p
Supplementary Table 10 - 13 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Supplementary Table 10: Antibodies for IHC and IF.Overview of antibodies used for stainings in human PDAC or KPC-derived tissues.Supplementary Table 11: Primer sequences for qRT-PCR.Primers for qRT-PCR-based quantification of ChIP and mRNA samples.Supplementary Table 12: Freezer dryer settings for sponge production.Specific settings for optimal sponge production.Supplementary Table 13: Explant media composition.List of reagents used for human PDAC and murine explants.</p
Supplementary Table 8 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Lymphoid network.Regulatory network for PDAC-associated lymphoid cells, listing the inferred transcriptional targets (Target) for each regulatory protein (Regulator). Association weight (AW) and association mode (AM) are scores to quantify strength/direction of interaction. Sign indicates directionality of the interaction (1 = transactivating, -1 = transrepressing).</p
Supplementary Figure 6 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Abrogation of SHH signaling fuels hypersprouting in human and murine PDAC explants.</p
Supplementary Table 5 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Endothelial network.Regulatory network for PDAC-associated endothelial cells, listing the inferred transcriptional targets (Target) for each regulatory protein (Regulator). Association weight (AW) and association mode (AM) are scores to quantify strength/direction of interaction. Sign indicates directionality of the interaction (1 = transactivating, -1 = transrepressing).</p
Supplementary Figure 2 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
IPI-926 treatment alters cellular composition in the tumor microenvironment.</p
Supplementary Figure 3 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Explant cellular populations.</p
Supplementary Figure 8 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Single cell analysis of paracrine cascades in KPC PDAC.</p