Epidemiologia delle parassitosi intestinali in una popolazione di immigrati extracomunitari

The Authors relate the results of an epidemiological study concerning the percentages of isolation for intestinal parasites in a population of out-community immigrant population that attends the ambulatory of “Jerry Masslo” voluntary Association in Castelvolturno, provence of Caserta, southern Italy. In the period that has gone since November 2001 to January 2003, 81 faecal samples of out-community immigrants were examined by standard coproparassitologyc examination: direct microscopic examination with iodine solution and with physiological solution, microscopic examination after enrichment with formalin-etilacetate and finally microscopic examination after permanent stain of Giemsa. Of all the examined samples, 44 (54.3%) were positive for one or more intestinal pathogenic parasites, while 37 (45.7%) were negative.The motivations to this study are to seek in the wish to give a contribution, even though least, to the understanding of the sanitary problems that this type of patients, the out-community immigrants, coming to make part in consistent way of our society more and more, has brought with itself

The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin

Empagliflozin (EMPA), a selective inhibitor of the sodium glucose co-transporter 2, reduced the risk of hospitalization for heart failure and cardiovascular death in type 2 diabetic patients in the EMPA-REG OUTCOME trial. Recent trials evidenced several cardio-renal benefits of EMPA in non-diabetic patients through the involvement of biochemical pathways that are still to be deeply analysed. We aimed to evaluate the effects of EMPA on myocardial strain of non-diabetic mice treated with doxorubicin (DOXO) through the analysis of NLRP3 inflammasome and MyD88-related pathways resulting in anti-apoptotic and anti-fibrotic effects