Characteristics of the study population according to Nt-proBNP quartiles.

<p>Data are presented as N(%) or median (25^th–75^th). P values correspond to one-way ANOVA.</p><p>LVEF: Left Ventricular Ejection Fraction.</p><p>CK: Creatine Kinase.</p><p>Nt-proBNP: N-terminal pro B type Natriuretic Peptide.</p><p>MI: Myocardial Infarction.</p

Incremental value of post-operative GDF-15 to predict AKIN after CABG surgery.

<p>Bar graph illustrating the change in global χ2 value by the addition of post-operative GDF-15 and/or NGAL to post-operative eGFR. All models were significantly associated with AKI (p<0.05). * = p<0.05 vs eGFR model. § =  p = 0.06 vs eGFR + NGAL model.</p

Time course of plasma GDF-15 (A) and FSTL-1 (B) levels in patients (n = 34) undergoing cardiac surgery associated with CPB.

<p>Values, corrected for hemodilution, are mean ± SEM, *: significantly different (p<0.05) between time-point and IND levels (One way repeated measures ANOVA, followed by pair-wise comparison of mean levels with Tukey test).</p

Heart rate variability parameters in spectral analysis according to of Nt-proBNP quartiles: Low Frequency (LF), High Frequency (HF) and Low frequency/High Frequency (LF/HF) ratio.

<p>P values correspond to one-way ANOVA.</p

Distribution of heart rate variability indexes according to Nt ProBNP quartiles.

<p>Data are presented as median (25^th–75^th). P values correspond to one-way ANOVA.</p

Correlation analysis between Nt-proBNP circulating levels and heart rate variability parameters on 24 h holter ECG ; A: SDNN: Standard Deviation of the NN interval (SDNN); B: Low frequency (LF); C: High frequency (HF = ; D: Low frequency/high frequency (LF/HF) ratio.

<p>P values correspond to one-way ANOVA. LF and HF are log-transformed values.</p

Cardiovascular outcomes according to Symmetric dimethylarginine tertiles values (<i>p</i> value for comparison between the tertiles).

<p>Cardiovascular outcomes according to Symmetric dimethylarginine tertiles values (<i>p</i> value for comparison between the tertiles).</p

Association between induction plasma GDF-15 concentration and baseline clinical and biological variables¹.

1<p>p-value and Spearman's rank correlation was for used for testing the association of GDF-15 at IND to the baseline clinical and biological variables.</p><p>Association between induction plasma GDF-15 concentration and baseline clinical and biological variables^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0105759#nt101" target="_blank">1</a>}.</p

Intraoperative data and postoperative outcomes.

<p>Intraoperative data and postoperative outcomes.</p

Correlations between post-operative ICU GDF-15 levels and markers of renal and cardiac injury: plasma levels of cTnI (μg/L) at IND, post-SURG and ICU (A), correlation between plasma levels of GDF-15 and cTnI ICU (B), plasma levels of NGAL (ng/mL) at IND, post-SURG and ICU (C), correlation between plasma levels of GDF-15 and NGAL at the ICU (D).

<p>(One way repeated measures ANOVA followed by pair-wise comparison of mean levels with Tukey test; Spearman’s correlation, n = 34).</p