Module d'enseignement informatisé et interactif sur les affections de l'ombilic chez le poulain

LYON1-BU Santé (693882101) / SudocSudocFranceF

Lyme disease in horses : a clinical and diagnostical challenge

La maladie de Lyme, infection causée par des bactéries spirochètes du genre Borrelia, reste une maladie controversée chez le cheval. De nombreux signes cliniques non spécifiques ont été attribués à cette maladie sur le terrain (fatigue, boiteries, troubles du comportement, hyperesthésie, fonte musculaire, fièvre isolée…) alors qu’ils n’ont jamais été reproduits lors d’infections expérimentales. La symptomatologie exacte lors d’infection naturelle reste très peu documentée, les rares cas publiés dans la littérature correspondent à des tableaux cliniques peu fréquents et probablement sous-diagnostiqués (uvéite, neuroborréliose et atteinte cutanée de type « pseudo-lymphome »). Les tests sérologiques restent les examens complémentaires les plus utilisés, la PCR sur le sang étant presque systématiquement négative. Néanmoins, les résultats sérologiques doivent être interprétés avec précaution : un résultat positif traduit une exposition au pathogène, ce qui ne veut pas dire que le cheval souffre de maladie de Lyme (la plupart des infections étant asymptomatiques). D’autre part, un résultat négatif ne permet pas d’exclure totalement l’hypothèse (du fait de la cinétique particulière des anticorps et de la variabilité des réponses immunitaires). Actuellement, le traitement se justifie sur des chevaux sérologiquement positifs présentant des signes cliniques pour lesquels les autres causes potentielles ont été exclues. Il n’existe pas de consensus sur le choix du protocole mais les tétracyclines sur plusieurs semaines restent les plus utilisées. Enfin, il est reconnu qu’une réponse positive au traitement ne peut être utilisée comme critère diagnostique.Lyme disease, caused by the bacterial spirochete Borrelia, is still controversial in horses. Many non specific clinical signs have been attributed to this disease (fatigue, lameness, behavioral changes, hyperesthesia, muscle tenderness, fever…) but they have never been reproduced experimentally. The exact symptomatology during natural infection is poorly documented, only few clinical cases of three rare syndromes have been reported (uveitis, neuroborreliosis and Borrelia-associated cutaneous pseudolymphoma). Serological testing are commonly used, as PCR on blood are almost always negative. However, serological results should be interpreted with caution: a positive serology means exposure to the Borrelia organism but not that the horse suffers from Lyme disease (as many infections are asymptomatic). Besides, a negative serology does not rule out the hypothesis (because of antibodies kinetic and immune response variability). Nowadays, treatment is recommended only in horses with a positive serology and clinical signs compatible with Lyme disease, after exclusion of other causes. The ideal protocol is unknown but tetracyclines during several weeks are most commonly used. Last, it is well recognized that a positive response to treatment cannot be used as a diagnostic aid

Effect of training and racing on bronchoalveolar lavage cytology in Standardbred racehorses

International audienc

Association between bronchoalveolar lavage fluid cytology and performance in Standardbred racehorses

International audienc

Longitudinal follow-up of bronchoalveolar lavage cytology in Standardbred racehorses

International audienc

Longitudinal Follow-Up of Bronchoalveolar Lavage Cytology in Standardbred Racehorses

International audienc

Cardiac variables of eventing horses at rest and after cross-country in international competitions

International audienc

Syndrome de fibrose pulmonaire multinodulaire et herpesvirus équin -5: investigations cliniques, moléculaires et possibilités thérapeutiques

International audienc

Cardiac variables of eventing horses at rest and after cross-country in international competitions

International audienc

Ultrasonographic features of PMEL17 ( Silver ) mutant gene-associated multiple congenital ocular anomalies (MCOA) in Comtois and Rocky Mountain horses

OBJECTIVE: (1) To describe the ultrasonographic appearance of multiple congenital ocular anomalies (MCOA) in the eyes of horses with the PMEL17 (Silver) mutant gene. (2) To compare the accuracy of B-mode ocular ultrasound to conventional direct ophthalmoscopy. ANIMALS STUDIED: Sixty-seven Comtois and 18 Rocky Mountain horses were included in the study. PROCEDURES: Horses were classified as being carriers or noncarriers of the PMEL17 mutant allele based on coat color or genetic testing. Direct ophthalmoscopy followed by standardized ultrasonographic examination was performed in all horses. RESULTS: Seventy-five of 85 horses (88.24%) carried at least one copy of the Silver mutant allele. Cornea globosa, severe iridal hypoplasia, uveal cysts, cataracts, and retinal detachment could be appreciated with ultrasound. Carrier horses had statistically significantly increased anterior chamber depth and decreased thickness of anterior uvea compared with noncarriers (P < 0.05). Uveal cysts had a wide range of location and ultrasonographic appearances. In 51/73 (69.86%) carrier horses, ultrasound detected ciliary cysts that were missed with direct ophthalmoscopy. CONCLUSIONS: In this study, ultrasonography was useful to identify uveal cysts in PMEL17 mutant carriers and to assess anterior chamber depth