Proportion of babies reporting infectious disease symptoms by week over the first year (mITT cohort).

<p>Proportion of babies reporting infectious disease symptoms by week over the first year (mITT cohort).</p

Participant disposition by randomization group, showing modified intent-to-treat (mITT) and modified per-protocol (mPP) cohorts.

<p>Participant disposition by randomization group, showing modified intent-to-treat (mITT) and modified per-protocol (mPP) cohorts.</p

Maternal and household characteristics at enrollment, by intervention group (ITT cohort^a).

<p>Maternal and household characteristics at enrollment, by intervention group (ITT cohort<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0199298#t001fn002" target="_blank">^a</a>).</p

Comparison of quantitative RT-PCR vs. PCR assays for detection of MXPyV and titers of MXPyV in stool.

<p>Abbreviations: Mex, Mexico; CA, California.</p><p>-, not detected by qPCR.</p>*<p>, not tested by PCR because of sample unavailability or because sample was negative by qRT-PCR but positive by other qualitative RT-PCR assays.</p

Genome organization of MXPyV.

<p>The 4,939-nt circular genome of MXPyV (<b>A</b>) contains putative coding regions for VP1, VP2, VP3, ST-Ag, and LT-Ag (yellow arrows). C1, C2, and C3 (gray) denote <i>de novo</i> assembled contigs from deep sequencing data. (<b>B</b>) Domains and binding motifs present in the spliced LT-Ag and ST-Ag of MXPyV.</p

Amino acid identities of the VP1, VP2, small T-antigen, large T-antigen of MXPyV relative to that of other polyomaviruses.

<p>Amino acid identities of the VP1, VP2, small T-antigen, large T-antigen of MXPyV relative to that of other polyomaviruses.</p

Gastroenteritis symptoms corresponding to MXPyV-positive stool samples compared to uninfected samples in the California SIFT study.

<p>Gastroenteritis symptoms corresponding to MXPyV-positive stool samples compared to uninfected samples in the California SIFT study.</p

Whole-genome sequence alignment of MXPyV relative to other recently described gut-associated polyomaviruses HPyV10 and MWPyV.

<p>Whole-genome sequence alignment of MXPyV relative to other recently described gut-associated polyomaviruses HPyV10 and MWPyV.</p

Results from MXPyV screening of clinical samples by RT-PCR.

*<p>includes initial MXPyV-positive sample identified by deep sequencing.</p>**<p>Stanford Infection and Familial Transmission Study.</p

Amino acid phylogenetic analysis of MXPyV relative to other polyomaviruses.

<p>(<b>A</b>) VP1, (<b>B</b>) VP2, (<b>C</b>) ST-Ag, (<b>D</b>) LT-Ag. Bayesian support levels are indicated at each branching point. Abbreviations: AGM, African green monkey; SV40, simian virus 40; SV12, simian virus 12; SqMPy, squirrel monkey; CaliSeaLion, California sea lion. Other abbreviations and GenBank accession numbers are described in the text. Note that Merkel cell virus (MCV) is not included in the LT-Ag phylogeny due to the presence of truncation mutations.</p