2 research outputs found
Morphological and functional characterizations of Schwann cells stimulated with Mycobacterium leprae
Morphological and functional characterizations of Schwann cells stimulated with Mycobacterium leprae
Nerve damage, a characteristic of leprosy, is the cause of patient
deformities and a consequence of Schwann cells (SC) infection by
Mycobacterium leprae . Although function/dysfunction of SC in human
diseases like leprosy is difficult to study, many in vitro models,
including SC lines derived from rat and/or human Schwannomas, have been
employed. ST88-14 is one of the cell lineages used by many researchers
as a model for M. leprae/SC interaction. However, it is necessary to
establish the values and limitations of the generated data on the
effects of M. leprae in these SC. After evaluating the cell line
phenotype in the present study, it is close to non-myelinating SC,
making this lineage an ideal model for M. leprae/SC interaction. It was
also observed that both M. leprae and PGL-1, a mycobacterial cell-wall
component, induced low levels of apoptosis in ST88-14 by a mechanism
independent of Bcl-2 family members