Biomarkers assayed by RT-PCR in lung tissue.

<p>TGF, transforming growth factor; VEGF, vascular endothelial growth factor, PPAR, peroxisome proliferator-activated receptor; BMP, bone morphogenetic protein; Eln, Elastin; Col1a1, Collagen, Type 1, alpha 1; TIMP1, TIMP metallopeptidase inhibitor 1; LOXL2, lysyl oxidase homolog 2; MMP, matrix metalloproteinase; CRP, C-reactive protein; IL, interleukin; CXCL2, chemokine (C-X-C motif) ligand 2; CD46, CD46 complement regulatory protein; ICAM-1, intracellular adhesion molecule 1; CCL5, Chemokine (C-C motif) ligand 5; TNF, tumor necrosis factor.</p

Fold change in gene expression within studied physiologic categories of lung development across experimental groups.

<p><b>Bold</b>  =  greater than a 2-fold change and/or p<0.05; values <1 represent down-regulation;</p><p>values >1 represent up-regulation.</p>a<p>Relative to the Room Air group;</p>b<p>Relative to the Hyperoxia alone group.</p><p>*p = 0.05,</p><p>**p<0.05.</p

Pup growth patterns by experimental group.

<p>RA, room air; H, hyperoxia; RvD1, Resolvin D1; LXA₄, Lipoxin A₄. *p<0.05 compared to Hyperoxia group.</p

Lung histology by treatment group.

<p>Representative images of H and E stained sections were taken at an original magnification of 200x. Bars represent 100 µm. RvD1, Resolvin D1; LXA₄, Lipoxin A₄.</p

Morphometric assessment of lung histology.

<p>Shown in Figure 3A, B, and C are the morphometric assessment of the mean linear intercept (MLI), radial alveolar count (RAC) and septal thickness (ST) respectively. Bars represent means +/- SEM. 37 mice were analyzed for the MLI and ST morphometric measures. A mean of 6 images were analyzed per section/mouse. 34 mice were analyzed for RAC. A mean of 3 images were analyzed per section per mouse. RA, room air; H, hyperoxia; RvD1, Resolvin D1; LXA₄, Lipoxin A₄ a = p<0.05 compared to RA group; b = p<0.05 compared to Hyperoxia alone group; c = p<0.05 compared to the Hyperoxia + RvD1 group.</p