MSRV-type mRNA expression by PBMC from IM patients and healthy donors (HD).

<p>The amounts of MSRV-type HERV-Wenv transcripts were evaluated by discriminatory real time RT-PCR, and normalized by the 2^−ΔCt method (see Methods for details). Data are expressed as medians (line), with maximum and minimum values (whiskers); boxes represent interquartile range of the samples. Statistical significance was evaluated by the Mann-Whitney U-test for comparison of two groups, and by the Kruskal-Wallis test for three or four groups. (<b>A</b>) Comparison of IM patients (N = 17) and all healthy donors (HD, N = 24). (<b>B</b>) Comparison of IM patients (N = 17) and HD donors stratified according to plasmatic anti-EBNA-1 IgG titers, as EBV-negative (EBV−, N = 9), <600 IU/ml (N = 7), and >600 IU/ml (N = 8). Kruskall-Wallis test gave p = 0.0005 for all four groups, and p = 0.014 for the three HD groups.</p

Demographic and clinical characteristics of patients hospitalized with infectious mononucleosis and of healthy controls.

a<p>data are expressed as EBNA-1 DNA copies/ml of plasma. Detection limits: 100 copies/ml of plasma;</p>b<p>bl, borderline;</p>c<p>not done.</p