Additional file 1: Table S1. of Subjective health complaints in adolescent victims of cyber harassment: moderation through support from parents/friends - a Swedish population-based study

Estimated regression coefficients (95 % confidence intervals (CI)) for the association between cyber harassment, parental/friend support, and subjective health complaints (SHC) among 9th grade boys in Sweden, additionally adjusted for traditional bullying victimization. (DOC 17 kb

Additional file 2: Table S2. of Subjective health complaints in adolescent victims of cyber harassment: moderation through support from parents/friends - a Swedish population-based study

Estimated regression coefficients (95 % confidence intervals (CI)) for the association between cyber harassment, parental/friend support, and subjective health complaints (SHC) among 9th grade girls in Sweden, additionally adjusted for traditional bullying victimization. (DOC 17 kb

Additional file 1: Table S1. of Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment

Clinical characteristics of participants not included in the analysis due to missing blood samples. Table S2. Multivariate linear regression models of the effect of different treatment regimes on the change in fasting levels of hs-GH over 12 months in BCAPS. Adjusted for LDL-C at baseline and at 12 months. (DOCX 16 kb

Baseline characteristics of USE-IMT cohorts in the present analysis.

<p>Baseline characteristics of USE-IMT cohorts in the present analysis.</p

Relation between numbers of risk factors and differences in CIMT by race-ethnic group.

<p><b>Each number of risk factors was compared to individuals without any risk factor (reference group). CIMT, mean common carotid intima media thickness.</b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173393#pone.0173393.g003" target="_blank">Fig 3</a> presents the main findings of the overall analysis on risk factor clusters and CIMT. Within each risk factor cluster, there were graded relations with common CIMT. Within those with two risk factors, the cluster blood pressure-smoking had the highest CIMT (mean difference of 0.077 mm with those without risk factors) and the cluster with overweight- total cholesterol the least thickening (mean difference of 0.039 mm with those without risk factors), a difference reaching statistical significance with the cluster since the 95 confidence limits did not overlap. For people within the three risk factor cluster, elevated blood pressure, overweight and smoking had the highest common CIMT (0.084 mm). The pattern of the relationship between risk factor clusters and common CIMT were similar between sexes and race-ethnic groups, although some variation was observed between race-ethnic groups but was not significant due to limited minority samples sizes (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173393#pone.0173393.s001" target="_blank">S1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173393#pone.0173393.s002" target="_blank">S2</a> Figs). The interaction terms were not statistically significant.</p

Relation between risk factor clusters and differences in CIMT (Overall).

<p><b>Each cluster was compared to individuals without any risk factor (reference group).</b> CIMT, mean common carotid intima media thickness. BP, elevated blood pressure; OW, overweight; TC, elevated total cholesterol; smoking, current smoking.For most of the risk factors, the sum of the individual risk factor differences was smaller than the observed mean difference for the cluster in the overall analyses. For example, the mean difference in common CIMT for the blood pressure—smoking cluster was 0.077 mm, whereas the sum of the individual risk factors was 0.053 (i.e., 0.031 + 0.022). A similar finding was found for the smoking-blood pressure- overweight cluster. This observation suggests synergetic effects of risk factors on CIMT.</p

Relation between numbers of risk factors and difference in CIMT (Overall and by sex).

<p>Each number of risk factors was compared to individuals without any risk factor (reference group). CIMT, mean common carotid intima media thickness.</p

Effects of the Framingham risk factors in race/ethnic groups for the outcomes log CIMT (betas) and CV events (hazard ratios).

<p>The top half of the table displays betas and 95% confidence intervals of the Framingham risk factors for log CIMT for each race/ethnic group. The bottom half of the table displays hazard ratios and 95% confidence intervals of the Framingham risk factors for CV events for each race/ethnic group. The % difference columns express the percentage difference in effect size (beta or hazard ratio) as compared to the White race/ethnic group. Risk factors printed in bold have significantly different effect sizes among race/ethnic groups (significant interaction).</p><p>^a Indicates significant difference as compared to Whites (p<0.05)</p><p>^b Cardiovascular events (first-time stroke or MI).</p><p>Effects of the Framingham risk factors in race/ethnic groups for the outcomes log CIMT (betas) and CV events (hazard ratios).</p

Association between risk factors and mean common CIMT, by ethnicity.

<p>Point estimates for betas, lines represent 95% confidence intervals.</p

Details of participating USE-IMT cohorts.

<p>Abbreviations. ARIC: Atherosclerosis Risk in Communities Study; CAPS: Carotid Atherosclerosis Progression Study; CHS: Cardiovascular Health Study; CIRCS: Circulatory Risk in Communities Study; EAS: Edinburgh Artery Study; FATE: The Firefighters and Their Endothelium Study; Hoorn: The Hoorn Study; KIHD: Kuopio Ischaemic Heart Disease Risk Factor Study; Malmö: Malmö Diet and Cancer Study, MESA; Multi-race/ethnic Study of Atherosclerosis; NBS: Nijmegen Biomedical Study 2; NOMAS: Northern Manhattan Study; OSACA2: Osaka Follow-Up Study for Carotid Atherosclerosis 2; Tromsø: Tromsø Study; Whitehall: Whitehall II Study; CIMT: mean common carotid intima media thickness; FU: follow-up duration; MI: myocardial infarction; USA: United States of America; UK: United Kingdom; NLD: The Netherlands.</p><p>Details of participating USE-IMT cohorts.</p