Association between age and cellular immune response to different influenza A virus strains.

<p>The potential and the shape of association between age and T-cell response against A/H3N2/Min/11/10, A/H3N2/Ind/08/11 and A/H1N1/Cal/07/09 is shown for HD (left panels) and HIV+ (right panels) was analyzed by linear regression model. Departure from linear trend was assessed by model based likelihood ratio test (LTR) to assess the model including age as polynomial predictor.</p

Correlation between humoral immune response to H3N2v strains.

<p>(A): The correlation between HAI titers to A/H3N2/Min/11/10 and to A/H3N2/Ind/08/11 is shown in HD. Pearson's r² and significance, as well as the calculated regression line. (B): The correlation between HAI titers to A/H3N2/Min/11/10 and to A/H3N2/Ind/08/11 is shown in HIV+. Pearson's r² and significance, as well as the calculated regression line.</p

Frequency of HD and HIV+ presenting a T-cell response to different influenza A virus strains.

<p><b>* chi-square test:</b></p><p>**p = 0.0023.</p><p>Frequency of HD and HIV+ presenting a T-cell response to different influenza A virus strains.</p

Cellular immune response to different influenza A virus strains.

<p>(A): The frequency of T-cell response specific for A/H3N2/Min/11/10, A/H3N2/Ind/08/11 and for A/H1N1/Cal/07/09 was evaluated by ELISpot assay in HD (n = 45, white bars) and HIV+ patients (n = 46 grey bars). Results are indicated as SCFs/10⁶ peripheral mononuclear cells (PBMCs). Statistical analysis was performed using non parametric Mann-Whitney assay. ** p<0.0001. (B): The correlation between T-cell response against A/H3N2/Min/11/10 and A/H3N2/Ind/08/11 is shown, with Pearson's r² and significance, as well as the calculated regression line. HD and HIV+ are reported as white and black circles, respectively.</p

Association between age and humoral immune response to different influenza A virus strains.

<p>Age-related relationships of HAI titer against A/H3N2/Min/11/10, A/H3N2/Ind/08/11 and A/H1N1/Cal/07/09 in either HD (left panels) or HIV+ patients (right panels) was assessed by linear regression model. Departure from linear trend was assessed by model based likelihood ratio test (LTR) to assess the model including age as polynomial predictor.</p

Humoral immune response to different influenza A virus strains in HD and HIV-infected subjects.

<p><b>° HAI titer ≥40.</b></p><p><b>°° geometric mean of HAI titer.</b></p><p><b>* Chi-square test:</b></p><p>* p = 0.043.</p><p>** p = 0.0055.</p>§<p><b>: Kruskall-Wallis test.</b></p>§<p><b>:</b> p = 0.014.</p>§§<p>: p = 0.0043.</p><p>Humoral immune response to different influenza A virus strains in HD and HIV-infected subjects.</p

Characterization of enrolled subjects.

<p>Characterization of enrolled subjects.</p

Results of influenza A/H1N1pdm serology in 211 crew members of the Italian military ship Scirocco.

<p>Results of influenza A/H1N1pdm serology in 211 crew members of the Italian military ship Scirocco.</p

Distribution of acute respiratory illness (ARI) and suspected A/H1N1pdm cases, according to the time of symptoms onset and to the results of Influenza A/H1N1pdm-specific serological tests.

<p><u>Black bars</u>: seropositives; <u>gray bars</u>: seronegatives.</p

Results of influenza A/H1N1pdm serology in 211 crew members of the Italian military ship Scirocco, according to respiratory illness reported during the cruise.

<p>Results of influenza A/H1N1pdm serology in 211 crew members of the Italian military ship Scirocco, according to respiratory illness reported during the cruise.</p