1 research outputs found
Proteolytic Nanoparticles Replace a Surgical Blade by Controllably Remodeling the Oral Connective Tissue
Surgical
blades are common medical tools. However, blades cannot
distinguish between healthy and diseased tissue, thereby creating
unnecessary damage, lengthening recovery, and increasing pain. We
propose that surgical procedures can rely on natural tissue remodeling
toolsenzymes, which are the same tools our body uses to repair
itself. Through a combination of nanotechnology and a controllably
activated proteolytic enzyme, we performed a targeted surgical task
in the oral cavity. More specifically, we engineered nanoparticles
that contain collagenase in a deactivated form. Once placed at the
surgical site, collagenase was released at a therapeutic concentration
and activated by calcium, its biological cofactor that is naturally
present in the tissue. Enhanced periodontal remodeling was recorded
due to enzymatic cleavage of the supracrestal collagen fibers that
connect the teeth to the underlying bone. When positioned in their
new orientation, natural tissue repair mechanisms supported soft and
hard tissue recovery and reduced tooth relapse. Through the combination
of nanotechnology and proteolytic enzymes, localized surgical procedures
can now be less invasive