1 research outputs found
Comparative Study of Microbial-Derived Phenolic Metabolites in Human Feces after Intake of Gin, Red Wine, and Dealcoholized Red Wine
The
analysis of microbial phenolic metabolites in fecal samples
from in vivo studies is crucial to understanding the potential modulatory
effects derived from polyphenol consumption and its overall health
effects, particularly at the gut level. In this study, the composition
of microbial phenolic metabolites in human feces collected after regular
consumption of either red wine, dealcoholized red wine, or gin was
analyzed by UPLC-ESI-MS/MS. Red wine interventions produce a change
in the content of eight phenolic acids, which are probably derived
from the catabolism of flavan-3-ols and anthocyanins, the main flavonoids
in red wine. Moreover, alcohol seemed not to influence the formation
of phenolic metabolites by the gut microbiota. A principal component
analysis revealed large interindividual differences in the formation
of microbial metabolites after each red wine polyphenol intervention,
but not after the gin intervention, indicating differences in the
gut microbial composition among subjects