2 research outputs found
Obesity as a risk factor for dengue shock syndrome in children
Background Dengue hemorrhagic fever (DHF) leads to high
morbidity and mortality if not be treated properly and promptly.
Obesity may play a role in the progression ofDHF to dengue shock
syndrome (DSS) and could be a prognostic factor.
Objective To evaluate childhood obesity as a prognostic factor
for DSS.
Methods We reviewed medical records of patients with DHF
and DSS admitted to Department of Child Health, Dr. Sardjito
Hospital, Yogyakarta between June 2008 and February 2011.
Subjects were aged less than 18 years and fulfilled WHO criteria
(1997) for DHF or DSS. The exclusion criteria were the dengue
fever, a milder form of disease, or other viral infections. Risk
factors for DSS were analyzed by logistic regression analysis.
Results Of342 patients who met the inclusion criteria, there were
116 DSS patients (33 .9%) as the case group and 226 DHF patients
(66.1%) as the control group. Univariate analysis revealed that
risk factors for DSS were obesity (OR= 1.88; 95%CI 1.01 to3.5 l) ,
secondary infection type (OR=0.82; 95%CI 0.41 to 1.63), plasma
leakage with hematocrit increase> 25% (OR=3.42; 95%CI 2.06
to 5.65), platelet count < 20,000/μL (OR= l.95; 95%CI 1.20 to
3 .16), and inadequate fluid management from prior hospitalization
(OR=9.ll; 95% CI 1.13 to 73.66). By multivariate analysis,
plasma leakage with hematocrit increase > 25% was associated
with DSS (OR=2.5 l; 95%CI 1.12 to 5.59), while obesity was not
associated with DSS (OR= l.03; 95%CI 0.32 to3.3 1).
Conclusion Obesity is not a risk factor for DSS, while plasma
leakage with hematocrit increase > 25% is associated with DSS