1 research outputs found
Sustainable Electrospun Poly(l‑lactic acid) Fibers for Controlled Release of the Mosquito-Repellent Ethyl Butylacetylaminopropionate (IR3535)
Fibers composed of poly(l-lactic acid) (PLLA)
and the
mosquito-repellent ethyl butylacetylaminopropionate (IR3535) were
prepared by solution electrospinning. Defect-free and uniform monoaxial
fibers with a diameter of the order of magnitude of 1 μm were
obtained. Thermogravimetric analyses showed that it is possible to
incorporate more than 40 m% of IR3535 into the PLLA fibers. Thermal
and structural characterization indicated that IR3535 facilitates
the crystallization of PLLA and formation of orthorhombic α-crystals
during electrospinning. IR3535 has a plasticizing effect on PLLA,
as detected by the decrease in the glass transition temperature. The
release of IR3535 from PLLA/IR3535 fibers to the environment was quantified
by thermogravimetric analysis at different temperatures ranging from
60 to 100 °C, suggesting rather slow evaporation of the repellent,
with a time constant of few days at body temperature. The observed
results indicate a possible use of electrospun PLLA/IR3535 fiber mats
as part of a long-lasting repellent-delivery system and application
in the field of combating diseases caused by mosquito bites