<i>B</i>. <i>bacilliformis</i> transmission routes.

<p>¹ Humans are the only known reservoir. ² Despite a report by Noguchi et al [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005863#ppat.1005863.ref006" target="_blank">6</a>], no confirmatory result has been published.</p

Main facts on Carrion's disease.

<p>Main facts on Carrion's disease.</p

Multi-locus sequence typing (MLST) information of Oroya Fever samples.

<p>Multi-locus sequence typing (MLST) information of Oroya Fever samples.</p

Phylogenetic tree of all the Sequence Types of <i>B</i>. <i>bacilliformis</i> as constructed an UPGMA cluster analysis with Bootstrap method.

<p>Phylogenetic tree of all the Sequence Types of <i>B</i>. <i>bacilliformis</i> as constructed an UPGMA cluster analysis with Bootstrap method.</p

Map of the geographical distribution of Carrion’s disease in Peru with the distribution of the SequenceTypes location.

<p>Map of the geographical distribution of Carrion’s disease in Peru with the distribution of the SequenceTypes location.</p

Detection limit for the 3 PCR approaches studied both for blood samples and dried blood spots.

<p>Detection limit for the 3 PCR approaches studied both for blood samples and dried blood spots.</p

Amplification sizes in different <i>Bartonella</i> spp. for each of the three PCR approaches in study.

<p>Amplification sizes in different <i>Bartonella</i> spp. for each of the three PCR approaches in study.</p

Correlations of serum biomarker concentrations and IgM and IgG levels against <i>B</i>. <i>bacilliformis</i>.

<p>Only biomarkers with statistical significant associations with antibody levels are shown. P-values were computed through unadjusted linear regressions. The grey area shows the 95% confidence interval for predictions from the linear model.</p

Epidemiologic and demographic characteristics of study participants stratified by RT-PCR, IgM and IgG results.

<p>Epidemiologic and demographic characteristics of study participants stratified by RT-PCR, IgM and IgG results.</p

Serum biomarker concentrations according to <i>B</i>. <i>bacilliformis</i> IgM and IgG serostatus.

<p>Boxplots illustrate the 25^th and 75^th quartiles, and whiskers the percentile 10–90 of biomarkers significantly associated with IgM or IgG seropositivity. P-values were computed through unadjusted linear regressions.</p