4 research outputs found
Alteration of serum and tumoral neural cell adhesion molecule (NCAM) isoforms in patients with brain tumors
The neural cell adhesion molecule (NCAM) is involved in the intercellular junctions of neurons and glial cells. We investigated its relevance as a biomarker in gliomas which main characteristic is their high invasiveness. We studied by Western blot the pattern of serum NCAM bands in patients with gliomas (n = 34), with brain metastasis of different primary cancers (n = 27) and with benign brain tumors (n = 22)] compared with healthy controls (n = 69). For densitometric analysis NCAM bands â„130 kDa (HMW) and <130 kDa (LMW) were clustered. We observed that glioma patients presented higher NCAM HMW and lower NCAM LMW levels than control subjects (P < 0.01). A similar pattern was found in patients with brain metastasis or brain benign tumors, suggesting that the pattern of serum NCAM bands would be useful to detect brain tumor pathology. On the other hand, serum NCAM expression was not associated with the main clinicopathological features of gliomas, including overall survival. Interestingly, we found that 9/12 patients with glioma showed a significant decrease in NCAM HMW/LMW ratio between 1â3 months after successful tumor removal. Thus, serum NCAM could be a useful marker for monitoring treatment. NCAM expression was also analyzed at tissular level in 59 glioma sections from paraffined tumors. We observed that NCAM immunostaining was inversely correlated with the histological grade of malignancy, remaining this association in a multivariate analysis. Besides, loss of NCAM staining was significantly associated with bad prognosis in an univariate analysis.Fil: Todaro, Laura Beatriz. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂa "Ăngel H. Roffo"; ArgentinaFil: Christiansen, Silvia Beatriz. Hospital Italiano; ArgentinaFil: Varela, Mirta. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂa "Ăngel H. Roffo"; ArgentinaFil: CampodĂłnico, Paola Bernadette. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂa "Ăngel H. Roffo"; ArgentinaFil: Pallotta Rodriguez, Maria Guadalupe. Hospital Italiano; ArgentinaFil: Lastiri, JosĂ©. Hospital Italiano; ArgentinaFil: Sacerdote de Lustig, Eugenia. Hospital Italiano; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂa "Ăngel H. Roffo"; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Bal, Elisa Dora. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂa "Ăngel H. Roffo"; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Puricelli, Lydia Ines. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂa "Ăngel H. Roffo"; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaUnidad documental simpl
AlteraciĂłn en los niveles de N-CAM soluble en pacientes con tumores cerebrales
En 1824 Dutrochet informĂł acerca de la capacidad que poseen los leucocitos de adherirse a las paredes de los vasos y de migrar a los tejidos circundantes...Fil: Todaro, Laura Beatriz. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂa "Ăngel H. Roffo"; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂa "Ăngel H. Roffo"; ArgentinaFil: Pallotta, MarĂa Guadalupe. Hospital Italiano; ArgentinaFil: Lastiri, JosĂ©. Hospital Italiano; ArgentinaFil: Ciraolo, C.. Hospital Italiano; ArgentinaFil: Lopez Lincuez, Maria Emilia. Hospital Italiano; ArgentinaFil: Bal de Kier JoffĂ©, E.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂa "Ăngel H. Roffo"; ArgentinaFil: Sacerdote de Lustig, Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de OncologĂa "Ăngel H. Roffo"; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Valera, M. S.. Hospital Italiano; Argentin