6 research outputs found
Clarity perceived about vaccine information between hesitant and non-hesitant (N = 172,314).
Clarity perceived about vaccine information between hesitant and non-hesitant (N = 172,314).</p
Brazilians perceived trustworthiness of sources of information about the vaccine for the prevention of COVID-19 according to vaccine hesitancy (n = 173,178, with 18,250 hesitant and 154,928 non-hesitant).
Some participants did not report trustworthiness in some information sources.</p
Number of participants who gave their opinion on the understanding of vaccine efficacy data according to vaccine hesitancy.
(N = 172,366 respondents, with 154,237 not hesitant and 18,129 hesitant).</p
Multivariate logistic regression to assess factors associated with trust in the information source.
Multivariate logistic regression to assess factors associated with trust in the information source.</p
Strategies indicated to increase the percentage of vaccine adherence to prevent COVID-19 according to the intention to vaccinate.
Strategies indicated to increase the percentage of vaccine adherence to prevent COVID-19 according to the intention to vaccinate.</p
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<p>Zika virus (ZIKV) disease has become a global health emergency with devastating effects on public health. Recent evidences implicate the virus as an emergent neuropathological agent promoting serious pathologies of the human nervous system, that include destructive and malformation consequences such as development of ocular and fetal brain lesions, microcephaly in neonates, and GuillainâBarrĂ© syndrome (GBS) in adults. These neurological disorders of both central and peripheral nervous systems are thought to be associated to the neurotropic properties of the virus that has ability to infect neural stem cells as well as peripheral neurons, a hallmark of its pathogenicity. The presence of autoantibodies against gangliosides plays a pivotal role in the etiogenesis of GBS and a variety of neurological disorders. Gangliosides are a class of galactose-containing cerebrosides mainly expressed in nervous system tissues playing a critical role in the physiology of neural cells and neurogenesis. Herein, our findings indicate that patients at acute phase of ZIKV infection without any neurological signs show increased levels of IgG autoantibody against GD3 gangliosides, a class of glycolipid found to be highly expressed in neural stem cell acting in the maintenance of their self-renewal cellular capacity. It is possible that a pathological threshold of these antibodies is only acquired in secondary or subsequent infections. In the light of these evidences, we propose that the target of GD3 by autoimmune responses may possibly has an effect in the neuropathy and neurogenesis disorder seen during ZIKV infection.</p