1 research outputs found
A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin
Ferrociphenols
are known to display anticancer properties by original
mechanisms dependent on redox properties and generation of active
metabolites such as quinone methides. Recent studies have highlighted
the positive impact of oxidative stress on chemosensitivity and prognosis
of ovarian cancer patients. Ovarian adenocarcinomas are shown to be
an excellent model for defining the impact of selected ferrociphenols
as new therapeutic drugs for such cancers. This work describes the
syntheses and preliminary mechanistic research of unprecedented multitargeting
heterocyclic ferrociphenols bearing either a succinimidyl or phthalimidyl
group that show exceptional antiproliferative behavior against epithelial
ovarian cancer cells resistant to cisplatin. Owing to the failure
of the present pharmaceutical options, such as carboplatin a metallodrug
based on Pt coordination chemistry, these species may help to overcome
the problem of lethal resistance. Currently, ferrociphenolic entities
generally operate via apoptotic and senescence pathways. We present
here our first results in this new cyclic-imide series