8 research outputs found
ChemInform Abstract: Substituted Benzo[d]oxazol-2(3H)-one Derivatives with Preference for the σ 1
Novel sigma ligands: design, preparation and biological evaluation.
Sigma receptors have been studied mostly with respect to their functions within the nervous system. Ligands showing high affinity for sigma-1 vs. sigma-2 subtypes are potential neuroprotective agents. Furthermore, the high densities of both receptor subtypes in many tumor cell lines and tissues suggested their involvement in cancer biology
3D pharmacophore model of sigma1 binding site based on a series of subtitued benzo[d]oxazol-2(3H)-one derivatives.
Detection and characterization of IgG, IgE, and IgA autoantibodies in patients with bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitors
BCL10 expression and localization in Ocular Adnexa MALT lymphomas: a comparative cytogenetic and immunohistochemical study
Summary. T(1;14) (p22;q32) involving BCL10 and IGH
genes is a rare but recurrent chromosomal aberration in
MALT-type lymphoma. It is rarely described in ocular
adnexa B cell lymphomas, although nuclear BCL10
shuttling seems to be critical for disease progression in
this district. We have evaluated the translocations MALT
lymphoma-related in a series of 45 ocular adnexa cases,
focusing in particular on their relation with BCL10
expression and its cellular topographic distribution. A
prognostic tissue microarray (TMA) with ocular adnexa
MALT lymphomas was designed. A study of BCL10
expression and its topographic distribution was
performed through immunohistochemistry. In addition
the assessment of t(14;18) (q32;q21), t(1;14) (p22;q32)
and t(11;18) (q21;q21) was determined by Fluorescent In
Situ Hybridization (FISH).
Our series revealed t(14;18) (q32;q21) in 6/43 cases
(14,3%). t(1;14) (p22;q32), never described in ocular
adnexa MALT lymphomas, was observed in 3/31
(9,7%), two of which exhibited the gain of 3’ upstream
BCL10 gene signal (4%), whereas no case showed
t(11;18) (q21;q21). Moreover, BCL10 expression was
observed in 18/45 cases. In particular its nuclear
expression was revealed in 12/45 cases, cytoplasmic
expression in 5/45 and both cytoplasmic and nuclear
expression in 1/45. Statistical analysis demonstrated that
while BCL10 cytoplasmic expression is significantly
related to the presence of the investigated chromosomal
aberrations, in particular with t(14;18) (q32;q21),
BCL10 nuclear shuttling does not show any correlation
with these translocations. Our data support that BCL10
nuclear distribution is neither related to BCL10
rearrangement nor to other known translocations
I.S.Mu.L.T. Achilles Tendon Ruptures Guidelines
This work provides easily accessible guidelines for the diagnosis, treatment and rehabilitation of Achilles tendon ruptures. These guidelines could be considered as recommendations for good clinical practice developed through a process of systematic review of the literature and expert opinion, to improve the quality of care for the individual patient and rationalize the use of resources. This work is divided into two sessions: 1) questions about hot topics; 2) answers to the questions following Evidence Based Medicine principles. Despite the frequency of the pathology andthe high level of satisfaction achieved in treatment of Achilles tendon ruptures, a global consensus is lacking. In fact, there is not a uniform treatment and rehabilitation protocol used for Achilles tendon ruptures