5 research outputs found
Co-circulation of Junin virus and other mammarenaviruses in a geographical area without confirmed cases of Argentine Hemorrhagic Fever
Get PDFDesde la identificaci贸n del virus Junin en la d茅cada del 50, se realizaron numerosos estudios en roedores silvestres dentro del 谩rea end茅mica de la Fiebre Hemorr谩gica Argentina (FHA) que per-mitieron registrar, adem谩s, actividad del virus de la coriomeningitis linfocitaria (LCMV) y del virus Latino (LATV). La ausencia de casos confirmados de FHA desde la d茅cada del 90 en el departamento R铆o Cuarto, provincia de C贸rdoba, promovi贸 la vigilancia ecoepidemiol贸gica y de infecci贸n del Calomys musculinus (reservorio del virus Junin) y la b煤squeda de reservorios e infecci贸n de los otros mammarenavirus. Durante dos a帽os de muestreo estacional, con un sistema de captura, marcaci贸n y liberaci贸n capturamos 857 roedores, que correspondieron 57.3% a los reservorios: C. musculinus (especie m谩s abundante), C. venustus y Mus musculus. Detectamos anticuerpos y caracterizamos molecularmente los tres agentes virales. Observamos una prevalencia de infecci贸n de 3.5% (9/254) para virus Junin, 100% (3/3) para LCMV y 24.1% (21/87) para LATV. En conclusi贸n, demostra卢mos circulaci贸n de virus Junin en su roedor reservorio, en una regi贸n considerada hist贸rica para FHA con riesgo potencial para la poblaci贸n y cocirculaci贸n espacio-temporal de los tres mammarenavirus en la regi贸n central de Argentina.Since the identification of Junin virus in the 1950s, many studies were carried out in wild rodents within the endemic area of the Argentine Hemorrhagic Fever (AHF) that recorded also the activity of the lymphocytic choriomeningitis virus (LCMV) and the Latino virus (LATV). The absence of confirmed cases of AHF since the 1990s in the department of Rio Cuarto, C贸rdoba province, promoted ecoepidemiological surveillance of infection of Calomys musculinus (Junin virus reservoir) and the search of reservoirs of the other mammarenaviruses. During two years of seasonal sampling, with a capture, mark and release system, 857 rodents were captured, corresponding 57.3% to the rodent reservoirs: C. musculinus, C. venustus and Mus musculus, being the first the most abundant species. Antibodies were detected and the three viral agents were molecularly characterized, showing a prevalence of infection of 3.5% (9/254) for Junin virus, 100% (3/3) for LCMV and 24.1% (21/87) for LATV. In conclusion, we demonstrated Junin virus circulation in its rodent reservoir in a region considered historic for AHF with potential risk for the population and the spatio-temporal co-circulation of the three mammarenaviruses in the central region of Argentina.Fil: Calder贸n, Gladys Ethel. Direcci贸n Nacional de Instituto de Investigaci贸n. Administraci贸n Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Virales Humanas; ArgentinaFil: Provensal, Mar铆a Cecilia. Universidad Nacional de R铆o Cuarto. Facultad de Ciencias Exactas, Fisicoqu铆micas y Naturales. Departamento de Ciencias Naturales; ArgentinaFil: Martin, Maria Laura. Direcci贸n Nacional de Instituto de Investigaci贸n. Administraci贸n Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Virales Humanas; ArgentinaFil: Brito Hoyos, Diana Marcela. Universidad Nacional de R铆o Cuarto. Facultad de Ciencias Exactas, Fisicoqu铆micas y Naturales. Departamento de Ciencias Naturales; ArgentinaFil: Garcia, Jorge Braulio. Direcci贸n Nacional de Instituto de Investigaci贸n. Administraci贸n Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Virales Humanas; ArgentinaFil: Gonz谩lez Ittig, Ra煤l Enrique. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Diversidad y Ecolog铆a Animal. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas F铆sicas y Naturales. Instituto de Diversidad y Ecolog铆a Animal; ArgentinaFil: Levis, Silvana del Carmen. Direcci贸n Nacional de Instituto de Investigaci贸n. Administraci贸n Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Virales Humanas; Argentin
What happened to the house mouse: Modelling the occupancy of Mus musculus in an argentine city considering its urban growth
No full textThis work aimed to estimate occupancy probabilities of Mus musculus (house mouse) as a function of environmental (NDVI and distance to water bodies) and anthropogenic (proportion of paved streets, distances to illegal dumpsites and railways) variables and to explore the differences in occupancy according to temporal changes of urban growth. We used occupancy models to obtain predictive maps of M. musculus distribution in habitats with open spatial arrangements of the city of R铆o Cuarto in periods 2001-2003 and 2020, which was validated on the ground. The obtained map for the first period showed that the highest occupancy probabilities agreed with paved areas following a gradient to the outskirt of the city, where the lowest occupancy values coincided with those areas without any buildings and with high values of vegetation cover. The obtained map for 2020 conditional on the actual presence of an open spatial arrangement habitat, showed that the house mouse expanded its distribution range in the city, with low-medium probability values in zones where it was absent in the previous period. Data obtained from field validation would support the reliability of our predictive map. This work reinforces the importance of integrating spatial analysis, environmental and anthropogenic variables and occupancy data in an urban area. Mus musculus expanded its range of distribution in the city accompanying the increase in urbanization that R铆o Cuarto has experienced in the last 20 years. Considering the importance of M. musculus as an indicator of environmental degradation in urban areas, local authorities have now a spatially explicit tool to prioritize resources to detect vacant lots located in those areas predicted as mediumhigh occupancy probabilities and direct control policies on them.Fil: Antonelli, Cecilia Roc铆o. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente.; ArgentinaFil: San Miguel, Tom谩s Valent铆n. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente.; ArgentinaFil: de Angelo, Carlos Daniel. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente.; ArgentinaFil: Priotto, Jose Waldemar. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente.; ArgentinaFil: Provensal, Mar铆a Cecilia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente.; ArgentinaFil: Gomez, Maria Daniela. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Ciencias de la Tierra, Biodiversidad y Ambiente.; Argentin
Effective population size differences in calomys musculinus, the host of Jun铆n Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever
No full textArgentine hemorrhagic fever (AHF) is a serious endemic disease in Argentina, produced by Jun铆n virus, whose host is the Sigmodontinae rodent Calomys musculinus. Within the endemic area, human incidence and proportion of infected rodents remains high for 5-10 years after the first appearance of the disease (epidemic [E] zone) and then gradually declines to sporadic cases (historic [H] zone). We tested the hypothesis that host populations within the E zone are large and well connected by gene flow, facilitating the transmission and maintenance of the virus, whereas those in the H and nonendemic (NE) zones are small and isolated, with the opposite effect. We estimated parameters affected by levels of gene flow and population size in 14 populations of C. musculinus: population effective size (Ne), genetic variability, and mean relatedness. Our hypothesis was not supported: the lowest levels of variability and of Ne and the highest genetic relatedness among individuals were found in the H zone. Populations from the NE zone displayed opposite results, whereas those in the E zone showed intermediate values. If we consider that populations are first NE, then E, and finally H, a correlative decrease in Ne was observed. Chronically infected females have a low reproductive success. We propose that this would lower Ne because each cohort would originate from a fraction of females of the previous generation, and affect other factors such as proportion of individuals that develop acute infection, probability of viral transmission, and evolution of virulence, which would explain, at least partly, the changing incidence of AHF.Fil: Chiappero, Marina Beatriz. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Diversidad y Ecolog铆a Animal. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas F铆sicas y Naturales. Instituto de Diversidad y Ecolog铆a Animal; ArgentinaFil: Piacenza, Maria Florencia. Universidad Nacional de R铆o Cuarto. Facultad de Ciencias Exactas, Fisicoqu铆micas y Naturales. Departamento de Ciencias Naturales; ArgentinaFil: Provensal, Mar铆a Cecilia. Universidad Nacional de R铆o Cuarto; ArgentinaFil: Calder贸n, Gladys Ethel. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui; ArgentinaFil: Gardenal, Cristina Noemi. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Diversidad y Ecolog铆a Animal. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas F铆sicas y Naturales. Instituto de Diversidad y Ecolog铆a Animal; ArgentinaFil: Polop, Jaime Jose. Universidad Nacional de R铆o Cuarto; Argentin
Co-circulation of Junin virus and other mammarenaviruses in a geographical area without confirmed cases of Argentine Hemorrhagic Fever
Get PDFDesde la identificaci贸n del virus Junin en la d茅cada del 50, se realizaron numerosos estudios en roedores silvestres dentro del 谩rea end茅mica de la Fiebre Hemorr谩gica Argentina (FHA) que per-mitieron registrar, adem谩s, actividad del virus de la coriomeningitis linfocitaria (LCMV) y del virus Latino (LATV). La ausencia de casos confirmados de FHA desde la d茅cada del 90 en el departamento R铆o Cuarto, provincia de C贸rdoba, promovi贸 la vigilancia ecoepidemiol贸gica y de infecci贸n del Calomys musculinus (reservorio del virus Junin) y la b煤squeda de reservorios e infecci贸n de los otros mammarenavirus. Durante dos a帽os de muestreo estacional, con un sistema de captura, marcaci贸n y liberaci贸n capturamos 857 roedores, que correspondieron 57.3% a los reservorios: C. musculinus (especie m谩s abundante), C. venustus y Mus musculus. Detectamos anticuerpos y caracterizamos molecularmente los tres agentes virales. Observamos una prevalencia de infecci贸n de 3.5% (9/254) para virus Junin, 100% (3/3) para LCMV y 24.1% (21/87) para LATV. En conclusi贸n, demostra卢mos circulaci贸n de virus Junin en su roedor reservorio, en una regi贸n considerada hist贸rica para FHA con riesgo potencial para la poblaci贸n y cocirculaci贸n espacio-temporal de los tres mammarenavirus en la regi贸n central de Argentina.Since the identification of Junin virus in the 1950s, many studies were carried out in wild rodents within the endemic area of the Argentine Hemorrhagic Fever (AHF) that recorded also the activity of the lymphocytic choriomeningitis virus (LCMV) and the Latino virus (LATV). The absence of confirmed cases of AHF since the 1990s in the department of Rio Cuarto, C贸rdoba province, promoted ecoepidemiological surveillance of infection of Calomys musculinus (Junin virus reservoir) and the search of reservoirs of the other mammarenaviruses. During two years of seasonal sampling, with a capture, mark and release system, 857 rodents were captured, corresponding 57.3% to the rodent reservoirs: C. musculinus, C. venustus and Mus musculus, being the first the most abundant species. Antibodies were detected and the three viral agents were molecularly characterized, showing a prevalence of infection of 3.5% (9/254) for Junin virus, 100% (3/3) for LCMV and 24.1% (21/87) for LATV. In conclusion, we demonstrated Junin virus circulation in its rodent reservoir in a region considered historic for AHF with potential risk for the population and the spatio-temporal co-circulation of the three mammarenaviruses in the central region of Argentina.Fil: Calder贸n, Gladys Ethel. Direcci贸n Nacional de Instituto de Investigaci贸n. Administraci贸n Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Virales Humanas; ArgentinaFil: Provensal, Mar铆a Cecilia. Universidad Nacional de R铆o Cuarto. Facultad de Ciencias Exactas, Fisicoqu铆micas y Naturales. Departamento de Ciencias Naturales; ArgentinaFil: Martin, Maria Laura. Direcci贸n Nacional de Instituto de Investigaci贸n. Administraci贸n Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Virales Humanas; ArgentinaFil: Brito Hoyos, Diana Marcela. Universidad Nacional de R铆o Cuarto. Facultad de Ciencias Exactas, Fisicoqu铆micas y Naturales. Departamento de Ciencias Naturales; ArgentinaFil: Garcia, Jorge Braulio. Direcci贸n Nacional de Instituto de Investigaci贸n. Administraci贸n Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Virales Humanas; ArgentinaFil: Gonz谩lez Ittig, Ra煤l Enrique. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Diversidad y Ecolog铆a Animal. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas F铆sicas y Naturales. Instituto de Diversidad y Ecolog铆a Animal; ArgentinaFil: Levis, Silvana del Carmen. Direcci贸n Nacional de Instituto de Investigaci贸n. Administraci贸n Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Virales Humanas; Argentin
